Lisa C Brown,Gwyneth Zai,James L Kennedy et al.
Lisa C Brown et al.
Pharmacogenomic (PGx) testing is an evidence-based strategy to optimize the selection and dosing of certain psychotropic medications. An individual's genetics play a role in medication response through pharmacokinetic and pharmacodynamic me...
Diversifying Psychiatric Genomics: Globally Inclusive Strategies Toward Health Equity [0.03%]
精神疾病基因组学的多元化：面向健康公平的全球包容性策略
Paola Giusti-Rodríguez,Niran Okewole,Sanjeev Jain et al.
Paola Giusti-Rodríguez et al.
The underrepresentation of non-European researchers, participants, and datasets in psychiatric genetics hinders the understanding of mental health conditions and perpetuates health inequities. Ancestral diversity in research is crucial for ...
Chunyu Liu,Chunling Zhang,Stephen J Glatt
Chunyu Liu
Psychiatric genetics has evolved from candidate-gene studies to whole-genome sequencing efforts. With hundreds of disease-associated loci now identified, functional interpretation of the associated loci becomes the critical next step toward...
Tourette Syndrome [0.03%]
妥瑞氏症
Eric A Storch
Eric A Storch
Brittney O Jurgen,Erica L Greenberg
Brittney O Jurgen
Tourette syndrome (TS) is associated with dysregulated cortico-striatal-thalamo-cortical neural circuitry, of which the primary implicated neurotransmitters include dopamine, glutamate, and gamma-aminobutyric acid. Pharmacologic interventio...
Hala Katato,Jonathan A Muniz,Carmen Lopez-Arvizu et al.
Hala Katato et al.
This article provides an overview of evidence-based behavior therapy for Tourette syndrome (TS) in children, adolescents, and adults. First, this article describes evidence-based behavioral therapies for TS, examines their efficacy in rando...
Jonathan A Muniz,Joseph F McGuire,Kesley A Ramsey
Jonathan A Muniz
Tourette syndrome and persistent tic disorders (collectively, TS) are impairing childhood-onset neuropsychiatric conditions. Utilizing evidence-based assessments (EBA) is standard for effective and accurate screening, diagnosis, and monitor...
Neurocognitive Functioning in Tourette Syndrome: From Research Findings to Clinical Implementation [0.03%]
抽动症的神经认知功能：从研究结果到临床实施
Simon Morand-Beaulieu,Daniel Stark,Tara Murphy
Simon Morand-Beaulieu
Individuals living with Tourette syndrome (TS) may benefit from cognitive assessment, as it may elucidate specific difficulties for which someone could receive accommodation and highlight relative strengths to build upon. Eventually, cognit...
Deanna J Greene,Damion V Demeter,Ashley N Nielsen
Deanna J Greene
Tourette syndrome is defined by motor and vocal tics, yet our understanding of the pathophysiology of tics remains limited. Functional MRI (fMRI) can localize brain function related to the clinical phenomenology of tics. Here, we review ext...
The Role of CBGTC Synaptic Neurotransmission in the Pathophysiology of Tics [0.03%]
CBGTC突触神经传递在抽动发病机制中的作用
Harvey S Singer,Justin Pellicciotti
Harvey S Singer
The pathophysiology of tic disorders involves an alteration in the transmission of messages through the cortico-basal ganglia-thalamo-cortical circuit. A major requirement for the passage of a message through this circuit is an intact chemi...