Genomics of Suicidal Behaviors: What Can We Learn from Polygenic Scores? [0.03%]
基因组学与自杀行为：我们能从多基因评分中得到什么启发？
Gabriela Ariadna Martínez-Levy,Carlos Sabás Cruz-Fuentes,Marco Antonio Sanabrais-Jiménez
Gabriela Ariadna Martínez-Levy
Substantial evidence supports the role of genetic factors in suicide behaviors (SBs). The most recent and powered genome-wide association studies identified significant loci for suicide, suicide attempts, and suicide ideation. Nonetheless, ...
Seth Davin Norrholm
Seth Davin Norrholm
Posttraumatic Stress Disorder (PTSD) is a prevalent psychiatric condition characterized by intrusive thoughts, hyperarousal, avoidance, and negative cognitive alterations following traumatic events. While a significant portion of individual...
Heike Weber,John M Hettema,Jürgen Deckert et al.
Heike Weber et al.
Anxiety disorders are the most prevalent psychiatric conditions in the general population. Despite the early observation of family aggregation of anxiety disorders with a heritability of 30% to 50%, their exact genetic structure is not yet ...
Genomics of Attention Deficit Hyperactivity Disorder: What the Clinician Needs to Know [0.03%]
注意缺陷多动障碍的基因组学：临床医师需要了解什么
Jan Haavik
Jan Haavik
This report provides an update on current knowledge and applications of genomic research in attention deficit hyperactivity disorder (ADHD). The history, principles, and underlying assumptions for genetic studies on psychiatric disorders ar...
Mainstreaming Diagnostic Genetic Testing and Precision Medicine for Autism Spectrum Disorder: The Role of Child and Adolescent Psychiatrists [0.03%]
儿童和青少年精神病医生在自闭症谱系障碍的诊断遗传学检测及精准医疗中的作用
David H Ledbetter,Brenda Finucane,Daniel Moreno-De-Luca et al.
David H Ledbetter et al.
Autism Spectrum Disorder (ASD) is a neurodevelopmental psychiatric condition that shares significant clinical and genetic overlap with intellectualdisability (ID) and other neurodevelopmental disorders. Genetic testingin ASD lags far behind...
Andrew McQuillin,Roel A Ophoff
Andrew McQuillin
Bipolar disorder (BD) affects approximately 2% of the global population, characterized by alternating episodes of mania or hypomania, and depression. It comprises two main types: bipolar I disorder, marked by severe manic episodes, and bipo...
Recent Advances in Schizophrenia Genomics and Emerging Clinical Implications [0.03%]
schizophrenia基因组学的最新进展及潜在临床意义
Tim B Bigdeli,Philip D Harvey
Tim B Bigdeli
The conceptualization of schizophrenia has evolved from Emil Kraepelin's identification of "dementia praecox" as a distinct illness characterized by cognitive and functional deficits to the modern understanding of its complex nature. Recent...
Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies [0.03%]
神经性厌食症的遗传学：未来个性化治疗的展望
Jiayi Xu,Daria Igudesman,Laura M Huckins et al.
Jiayi Xu et al.
Anorexia nervosa (AN) is a debilitating and often refractory eating disorder that is unique among psychiatric disorders insofar as nutrition is key to recovery. Treatment options and efficacy are limited with no approved medications for AN....
Matthew W Halvorsen
Matthew W Halvorsen
Tourette syndrome (TS) and chronic tic disorder (CTD) are characterized by persistent verbal and motor tics of varying severity. We describe modern genetic studies of TS/CTD focused on common and rare variation, which quantify genetic risk ...
Dan J Stein,Anna Hartford
Dan J Stein
The ethics of psychiatric genetics and genomics is an emerging field, distinct from general genetics. Key ethical concerns include the implications for personhood and identity, the dual perception of psychiatric conditions as both afflictio...