J Emanuel Finet,David S Rosenbaum,J Kevin Donahue
J Emanuel Finet
Animal models of atrial fibrillation have taught us about mechanisms of this common disease. A variety of animal models exist, including models of lone atrial fibrillation and models of atrial fibrillation in the setting of heart failure, a...
New concepts in atrial fibrillation: neural mechanisms and calcium dynamics [0.03%]
心房颤动的新概念：神经机制和钙动力学
Chung-Chuan Chou,Peng-Sheng Chen
Chung-Chuan Chou
Atrial fibrillation (AF) is a complex arrhythmia with multiple possible mechanisms. It requires a trigger for initiation and a favorable substrate for maintenance. Pulmonary vein myocardial sleeves have the potential to generate spontaneous...
Steven A Lubitz,B Alexander Yi,Patrick T Ellinor
Steven A Lubitz
Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF...
William B Kannel,Emelia J Benjamin
William B Kannel
Atrial fibrillation (AF), an escalating dysrhythmia, is accountable for extensive population morbidity and mortality. In the United States, approximately 2.3 million people are presently diagnosed with AF and it is estimated that this preva...
Atul Khasnis,Ranjan K Thakur
Atul Khasnis
Atrial fibrillation (AF) has undoubtedly become one of the most well-studied arrhythmias today in terms of pathophysiology and diagnostic and therapeutic (interventional) electrophysiology. Although it lends itself to an apparently easy dia...
Atrial Fibrillation. Preface [0.03%]
心房颤动。前言
Ranjan K Thakur,Andrea Natale
Ranjan K Thakur
Atrial Fibrillation. Foreword [0.03%]
心房颤动。前言
Michael H Crawford
Michael H Crawford
Extended-release niacin/laropiprant: reducing niacin-induced flushing to better realize the benefit of niacin in improving cardiovascular risk factors [0.03%]
缓释烟酸/拉罗皮兰：减少烟酸引起的面部潮红以更好地发挥烟酸改善心血管危险因素的作用
John F Paolini,Harold E Bays,Christie M Ballantyne et al.
John F Paolini et al.
Treatment with niacin effectively improves multiple lipid parameters and cardiovascular outcomes. Widespread use of niacin, however, is limited by flushing, which is mediated primarily by prostaglandin D2 (PGD2). Laropiprant is a selective ...
Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: a systematic review [0.03%]
二肽基肽酶-4作为治疗2型糖尿病的新靶点的系统评价研究
Javaid H Wani,Jennifer John-Kalarickal,Vivian A Fonseca
Javaid H Wani
Type 2 diabetes mellitus is a metabolic disease leading to microvascular and macrovascular complications including coronary artery disease and stroke. Management of diabetes has been challenging, particularly in the presence of the enormous...
Intensity of antiplatelet therapy in patients with acute coronary syndromes and percutaneous coronary intervention: the promise of prasugrel? [0.03%]
急性冠脉综合征患者经皮冠状动脉介入术的抗血小板强度——替卡洛尔的前景如何？
Stephen D Wiviott
Stephen D Wiviott
Platelet activation and aggregation play key roles in the management of ischemic complications of acute coronary syndromes and percutaneous coronary intervention. Dual antiplatelet therapy with aspirin and the thienopyridine clopidogrel has...