Recognizing and Managing Secondary Hemophagocytic Lymphohistiocytosis in Adults: A Practical Clinical Guide [0.03%]
成人继发性噬血细胞综合征的诊断与处理：实用指南
Adi Zoref-Lorenz,Joseph Rocco,Daniella M Schwartz et al.
Adi Zoref-Lorenz et al.
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory syndrome triggered by infections, malignancies, or rheumatologic conditions. Effective management requires identifying and treating the acute trigge...
Benjamin H Durham
Benjamin H Durham
The histiocytic and dendritic cell neoplasms encompass a clinically heterogeneous group of disorders leading to tissue damage secondary to the accumulation and infiltration of pathologic cells thought to be derived from the dendritic or mon...
Clinical Characteristics and Treatment of Histiocytic Disorders in Children [0.03%]
儿童噬 histiocyte 性疾病的临床特征和治疗
Barbara A Degar,Jennifer T Huang,Jacob Bledsoe
Barbara A Degar
Several distinct histiocytic neoplasms occur in children. These diseases are rare and their behavior is remarkably variable. In this article, the clinical and histopathologic features of Langerhans cell histiocytosis, Juvenile Xanthogranulo...
Kejian Zhang,Lauren K Meyer,Rafal Machowicz et al.
Kejian Zhang et al.
Familial hemophagocytic lymphohistiocytosis (fHLH) represents a group of rare, inherited immune system disorders characterized by uncontrolled inflammatory responses. fHLH results from genetic mutations that impair CD8 T cell and natural ki...
Immune Effector Cell-associated Hemophagocytic Lymphohistiocytosis-like Syndrome (IEC-HS) [0.03%]
免疫效应细胞相关的噬血淋巴组织细胞增生症样综合征（IEC-HS）
Jerry C Lee,William T Johnson,Melissa Hines et al.
Jerry C Lee et al.
Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) is a complication of adoptive cell therapy. Presenting with clinical manifestations of hyperinflammation and surrogate indicators of hyperinflammation...
Nancy Berliner,Barbara Degar
Nancy Berliner
Macrophage Activation Syndrome: Not Just for Rheumatologists Anymore [0.03%]
巨噬细胞活化综合征：不仅仅是风湿病学家关注的问题
Sonia Iosim,Lauren A Henderson
Sonia Iosim
Macrophage activation syndrome (MAS) is a term that was originally used to describe a hyperinflammatory syndrome that developed in some patients with rheumatologic diseases. It is now clear that MAS and hemophagocytic lymphohistiocytosis (H...
Nitya Gulati,Erin Peckham-Gregory,D Williams Parsons et al.
Nitya Gulati et al.
Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by inflammatory lesions with clonal histiocytes. LCH is driven by activating mitogen-activated protein kinase (MAPK) pathway mutations. BRAFV600E is the most...
Clinical Characteristics and Treatment of Familial Hemophagocytic Lymphohistiocytosis [0.03%]
家族性噬血细胞综合征的临床特点与治疗
Lauren K Meyer,Camille Keenan,Kim E Nichols
Lauren K Meyer
Familial hemophagocytic lymphohistiocytosis (fHLH) comprises a group of autosomal recessive disorders characterized by germline loss-of-function variants that negatively impact lymphocyte cytotoxicity. These disorders exhibit variable clini...
The Role of the Microbiome in Cancer Therapies: Current Evidence and Future Directions [0.03%]
微生物组在癌症治疗中的作用：现有证据和未来方向
Julia Chalif,Naomi Goldstein,Yogita Mehra et al.
Julia Chalif et al.
The microbiome is essential for maintaining human health and is also a key factor in the development and progression of various diseases, including cancer. Growing evidence has highlighted the microbiome's significant impact on cancer devel...