David S Shulman,Brian D Crompton
David S Shulman
We assess the emerging role of liquid biopsies, particularly circulating tumor DNA (ctDNA), in sarcoma management. Preliminary studies suggest that ctDNA has multiple potential applications including, early detection in patients with cancer...
Candace L Haddox,David J Papke Jr,César Serrano
Candace L Haddox
Leiomyosarcomas (LMS) are mesenchymal malignancies with smooth muscle differentiation that most commonly arise in the uterus, retroperitoneum, and extremity. Clinical course is variable, and management differs by site of origin. Recently co...
Current Approaches to the Treatment of Pediatric Soft Tissue Sarcomas: Rhabdomyosarcoma and Nonrhabdomyosarcoma Soft Tissue Sarcomas [0.03%]
儿童软组织肉瘤的当前治疗方法：横纹肌肉瘤和非横纹肌肉瘤性软组织肉瘤
Aaron R Weiss,Andrea Ferrari,Leo Mascarenhas et al.
Aaron R Weiss et al.
Soft tissue sarcomas (STS) are rare mesenchymal tumors representing up to 7% of all cancers in children. In the pediatric population, rhabdomyosarcoma (RMS) is the most common histology while the remainder is composed of several distinct hi...
When Is It Important to Sequence Sarcomas and Other Mesenchymal Neoplasms? A Practical Guide to Molecular Testing [0.03%]
肉瘤及其他间叶源性肿瘤进行测序的时机？分子检测实用指南
Maria Del Carmen Rodriguez Pena,David J Papke Jr
Maria Del Carmen Rodriguez Pena
The increasingly widespread availability of next-generation sequencing has led to its incorporation as a diagnostic tool in pathology and a modality for identifying targetable alterations. However, sequencing is still a somewhat expensive a...
Elizabeth H Baldini,Alessandro Gronchi
Elizabeth H Baldini
Soft tissue sarcoma is a rare heterogeneous group of tumors made up of over 100 histologic types and subtypes. Expert pathology review is crucial to confirm the correct diagnosis prior to treatment. Multidisciplinary discussion and manageme...
Michael W Bishop
Michael W Bishop
Osteosarcoma is the most common primary bone malignancy of childhood and adolescence. Despite advances in cures for many pediatric neoplasms, outcomes for osteosarcoma have not significantly changed for nearly 4 decades and treatment is sim...
Sylvie Bonvalot,Aisha Miah,Bernd Kasper
Sylvie Bonvalot
DT is a rare monoclonal fibroblastic neoplasm with an unpredictable biologic behavior. Over the past 15 y, the worldwide approach to desmoid tumor (DT) has shifted dramatically from surgery, when feasible, to frontline active surveillance i...
Approaches to Ultra-Rare Sarcomas: Definitions, Diagnostics, and Therapies [0.03%]
超罕见肉瘤的诊治思路：定义、诊断和治疗策略
Alessandra Merlini,Angelo Paolo Dei Tos,Pan Pantziarka et al.
Alessandra Merlini et al.
Ultra-rare sarcomas are sarcomas with an incidence of 1 case per million inhabitants per year, in which rarity poses a barrier to conducting histotype-specific randomized studies. This manuscript provides practical information and reference...
Gastrointestinal Stromal Tumor: Current Approaches and Future Directions in the Treatment of Advanced Disease [0.03%]
胃肠道间质瘤：晚期疾病治疗的现状与未来方向
Carlo M Cicala,Sebastian Bauer,Michael C Heinrich et al.
Carlo M Cicala et al.
This review discusses the current and future landscape of advanced gastrointestinal stromal tumor (GIST) treatment. It covers the role of tyrosine kinase inhibitors (TKIs), specifically imatinib, and further treatment options, such as sunit...
Role of Hematopoietic Cell Transplantation in Pediatric and Adult Hemophagocytic Lymphohistiocytosis-Remaining Unknowns and Challenges [0.03%]
骨髓移植治疗噬血细胞综合征的作用及面临的挑战
Sarah Nikiforow,Christine N Duncan
Sarah Nikiforow
The main indication for allogeneic HSCT in children is primary/familial HLH but indications in adults are diverse, including malignancy-associated HLH. Matched related donors have historically been the preferred stem cell source (if not sha...