The Rapidly Evolving Landscape of the Biology and Therapy of Chronic Lymphocytic Leukemia [0.03%]
慢性淋巴细胞性白血病的生物学和治疗的发展现状
Jennifer R Brown,Matthew S Davids
Jennifer R Brown
Jennifer Huang,Mazyar Shadman
Jennifer Huang
Studies examining venetoclax in combination with anti-CD20 monoclonal antibodies and covalent Bruton tyrosine kinase inhibitors (BTKi) demonstrated a progression-free survival and in some cases overall survival benefit over chemoimmunothera...
Jennifer R Brown
Jennifer R Brown
Targeting Bruton tyrosine kinase (BTK) has revolutionized the therapy for chronic lymphocytic leukemia. As patients remain on therapy, however, resistance develops progressively over time. The most common mechanism of resistance to covalent...
Brian Sworder,Tanya Siddiqi
Brian Sworder
Immune-based therapies have redefined treatment strategies for a number of lymphomas including chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). This review highlights the evolution and efficacy of immune-based therap...
Frontline Treatment of Chronic Lymphocytic Leukemia with Continuous Bruton's Tyrosine Kinase Inhibitors: A Comprehensive Overview [0.03%]
布鲁顿酪氨酸激酶抑制剂持续治疗慢性淋巴细胞白血病的前线治疗：综合概述
Seema Ali Bhat,Jennifer A Woyach
Seema Ali Bhat
Continuous treatment with Bruton's tyrosine kinase (BTK) inhibitors is well established for chronic lymphocytic leukemia in the frontline setting. Long-term data shows near-normal life expectancy for patients who are treated with ibrutinib....
The Chronic Lymphocytic Leukemia Epigenome: A Powerful and Stable Framework for Understanding Biological and Clinical Heterogeneity [0.03%]
慢性淋巴细胞白血病表观基因组：理解生物和临床异质性的强大而稳定的框架
Antonio Perez-Castro,Lynne V Abruzzo,Christopher C Oakes
Antonio Perez-Castro
This review explores how epigenetic information, and in particular DNA methylation-based "epitypes," enhances our understanding of chronic lymphocytic leukemia (CLL) biology and prognosis. Epitypes correlate with B-cell maturation stages an...
Philip A Thompson,Erin M Parry
Philip A Thompson
Despite advances in the management of chronic lymphocytic leukemia (CLL), the transformation of CLL to an aggressive lymphoma, known as Richter transformation (RT), remains associated with dismal outcomes. Recent scientific studies deepen o...
Candida Vitale,Andrea Ferrario,Giulia Zamprogna et al.
Candida Vitale et al.
Autoimmune phenomena, particularly autoimmune cytopenias (AIC), are common complications in patients with chronic lymphocytic leukemia (CLL), arising from the interplay of predisposing genetic and immunologic conditions and extrinsic trigge...
Suzane George,Alberto S Pappo
Suzane George
Liposarcoma: Novel Approaches to Systemic Therapy and Multidisciplinary Care [0.03%]
腹膜后脂肪肉瘤：创新的全身治疗及多学科协作疗法
Emily Jonczak,Jonathan Trent,Christina Roland et al.
Emily Jonczak et al.
Retroperitoneal well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are rare tumors presenting as bulky abdominal tumors requiring multidisciplinary management in high-volume centers. Surgery is the mainstay of ...