Jenna-Lynn Senger,Hollie Power,Amy M Moore
Jenna-Lynn Senger
Electrical stimulation is emerging as a perioperative strategy to improve peripheral nerve regeneration and enhance functional recovery. Despite decades of research, new insights into the complex multifaceted mechanisms of electrical stimul...
Growth Factors to Enhance Nerve Regeneration: Approaching Clinical Translation [0.03%]
促进神经再生的生长因子：迈向临床转化
Sami Tuffaha,Erica B Lee
Sami Tuffaha
Following nerve injury, growth factors (GFs) are transiently upregulated in injured neurons, proliferating Schwann cells, and denervated muscle and skin. They act on these same cells and tissues to promote nerve regeneration and end-organ r...
George D Bittner,Sami Tuffaha,Jaimie T Shores
George D Bittner
Axons successfully repaired with polyethylene glycol (PEG) fusion tecnology restored axonal continuity thereby preventing their Wallerian degeneration and minimizing muscle atrophy. PEG fusion studies in animal models and preliminary clinic...
Gordon C Wong,Kevin C Chung
Gordon C Wong
Peripheral nerve injuries are prevalent and their treatments present significant challenges. Among the various reconstructive options, nerve conduits and wraps are popular choices. Advances in bioengineering and regenerative medicine have l...
J Michael Hendry,Linden K Head
J Michael Hendry
Modern end-to-side (ETS) nerve transfers have undergone several permutations since the early 1990's. Preclinical data have revealed important mechanisms and patterns of donor axon outgrowth into the recipient nerves and target reinnervation...
Jonathan E Isaacs,James J Drinane
Jonathan E Isaacs
Processed nerve allograft is a widely accepted tool for reconstructing peripheral nerve defects. Repair parameters that need to be considered include gap length, nerve diameter, nerve type (motor, sensory, or mixed), and the soft tissue env...
Robin T Wu,Johnny Chuieng-Yi Lu
Robin T Wu
Nerve autografts involve the transplantation of a segment of the patient's own nerve to bridge a nerve gap. Autografts provide biological compatibility, support for axonal regeneration, and the ability to provide an anatomic scaffold for re...
Physiology of Nerve Regeneration: Key Factors Affecting Clinical Outcomes [0.03%]
神经再生生理学：影响临床疗效的关键因素
Tessa Gordon
Tessa Gordon
Functional recovery after peripheral nerve injuries is disappointing despite surgical advances in nerve repair. This review summarizes the relatively short window of opportunity for successful nerve regeneration due to the decline in the ex...
Elizabeth A Graesser,Matthew S Parsons,Christopher J Dy et al.
Elizabeth A Graesser et al.
Ultrasound and magnetic resonance neurography are useful modalities to aid in the assessment of compressive neuropathies, although they are still limited in their resolution of nerve microstructure and their capacity to monitor postoperativ...
Compressive Neuropathies of the Upper Extremity: Anatomy for the Peripheral Nerve Surgeon [0.03%]
上肢压迫性神经病：外周神经外科医生的解剖学指南
Jonathan Leckenby,Hannah Smith,Michael Catanzaro et al.
Jonathan Leckenby et al.
Advance knowledge of anatomy is a prerequisite for the peripheral nerve surgeon. This article serves to provide an outline of anatomic regions where nerve entrapment or compression can occur. Each section is subdivided into anatomic regions...