Eric Marietta,Alberto Rubio-Tapia
Eric Marietta
Dysbiosis exists in both the small intestinal mucosa, as well as the fecal microbiome of patients with celiac disease. However, no clear signal has been associated with every patient with celiac disease. Rather, the intestinal microbiome of...
Eric Marietta,Rok Seon Choung,Alberto Rubio-Tapia et al.
Eric Marietta et al.
Celiac disease (CeD) is an autoimmune disease that is tightly associated with human leukocytes antigen DQ2 and DQ8, such that the absence of DQ2 and/or DQ8 will definitively rule out a diagnosis of CeD. DQ2 and DQ8 drive which gliadin pepti...
Isabel Hujoel,James A King,Amanda K Cartee et al.
Isabel Hujoel et al.
Recent data have highlighted that our prior understanding of the populations at risk for celiac disease (CeD) was narrow and limited. Individuals of all races, sexes, ages, socioeconomic classes, and geographic locations can develop CeD. Fu...
Complicated Celiac Disease: Refractory Celiac Disease and Seronegative Villous Atrophy Spectrum [0.03%]
复杂性乳糜泻：难治性乳糜泻和血清学阴性的肠病性肠炎谱系疾病
Gerd Bouma,Chris J Mulder,Christophe Cellier
Gerd Bouma
A subset of celiac disease (CD) patients is, or becomes, refractory to a gluten-free diet with persistent malabsorption and intestinal villous atrophy (VA). The most common cause of this condition is inadvertent gluten exposure but concomit...
Adam C Bledsoe,Amelie Therrien,Joseph A Murray
Adam C Bledsoe
There is an interest and need for non-dietary therapies for celiac disease. Recent regulatory meetings and expert consensus have set some guidance for clinical trials designs and drug development in this disease that has a unique paradigm. ...
Luca Elli,Govind K Makharia,Daniel A Leffler et al.
Luca Elli et al.
Follow-up of celiac disease (CeD) after diagnosis includes dietician education and assessment of gluten-free diet (GFD) adherence promoting resolution of symptoms, mucosal injury, and can reduce the risk of comorbidities including osteopeni...
Dawn W Adams,Isabel Comino,Benjamin Lebwohl
Dawn W Adams
The ability to accurately identify gluten in the diet before and after consumption can significantly impact celiac disease management. This article discusses provider- and patient-facing technologies and how these may be incorporated into c...
Kendra Weekley,David Gardinier,Anne R Lee et al.
Kendra Weekley et al.
A gluten-free diet (GFD) is the only treatment of celiac disease (CeD). A GFD is free from any food or substance with wheat, rye, and barley. CeD can be associated with micronutrient deficiencies including iron, folate, vitamin B12, vitamin...
Controversies and Opportunities of a Nonbiopsy Diagnosis for Celiac Disease [0.03%]
无活检的小肠组织学检查在乳糜泻诊断中的争议和机遇
Claire L Jansson-Knodell,Alberto Rubio-Tapia,Carol E Semrad
Claire L Jansson-Knodell
In this article, we will examine the role of biopsy in the diagnosis of celiac disease. We will cover the historical place biopsy has held, current practice for diagnosing celiac disease, advancement of serology testing, controversy of a no...
Carolina Ciacci,Dawn W Adams,Knut E A Lundin et al.
Carolina Ciacci et al.
Celiac disease (CeD) diagnosis traditionally relies on detecting serum antibodies against gluten, transglutaminase 2, and anti-endomysial antibodies, as well as confirming mucosal damage via intestinal biopsy. While serology is useful in di...