Victor Y L Leung,Vivian Tam,Danny Chan et al.
Victor Y L Leung et al.
Many challenges confront intervertebral disk engineering owing to complexity and the presence of extraordinary stresses. Rebuilding a disk of native function could be useful for removal of the symptoms and correction of altered spine kinema...
Barrett I Woods,Nam Vo,Gwendolyn Sowa et al.
Barrett I Woods et al.
Intervertebral disk degeneration is a common and potentially debilitating disease process affecting millions of Americans and other populations each year. Current treatments address resultant symptoms and not the underlying pathophysiology ...
Daisuke Sakai
Daisuke Sakai
The use of stem cell applications has been explored and aimed at regenerating the intervertebral disk. The microenvironment in which cells of the intervertebral disk reside is harsh; however, researchers have reported on many applications f...
Prosthetic total disk replacement--can we learn from total hip replacement? [0.03%]
全盘置换术的假体选择问题——能从髋关节置换中得到什么启示？
H Michael Mayer,Christoph J Siepe
H Michael Mayer
Total lumbar disk replacement has become a routine procedure in many countries. However, discussions regarding its use are ongoing. Issues focus on patient selection, technical limitations, and avoidance or management of complications or lo...
Teija Lund,Thomas R Oxland
Teija Lund
Adjacent segment degeneration (ASD) is a relatively common phenomenon after spinal fusion surgery. Whether ASD is a consequence of the previous fusion or an individual's predisposition to continued degeneration remains unsolved to date. Thi...
Jaro Karppinen,Francis H Shen,Keith D K Luk et al.
Jaro Karppinen et al.
Degenerative disk disease is a strong etiologic risk factor of chronic low back pain (LBP). A multidisciplinary approach to treatment is often warranted. Patient education, medication, and cognitive behavioral therapies are essential in the...
Sharmila Majumdar,Thomas M Link,Lynne S Steinbach et al.
Sharmila Majumdar et al.
Low back pain has a negative impact on the economy and society. Intervertebral disk degeneration is linked to the occurrence of low back pain. MRI provides three-dimensional morphologic and biochemical information regarding the status of th...
Nozomu Inoue,Alejandro A Espinoza Orías
Nozomu Inoue
Degenerative changes in the material properties of nucleus pulposus and anulus fibrosus promote changes in viscoelastic properties of the whole disc. Volume, pressure and hydration loss in the nucleus pulposus, disk height decreases and fis...
Genetics of lumbar disk degeneration: technology, study designs, and risk factors [0.03%]
腰椎间盘退变的遗传学：技术、研究设计和风险因素
Patrick Yu-Ping Kao,Danny Chan,Dino Samartzis et al.
Patrick Yu-Ping Kao et al.
Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of...
Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites [0.03%]
椎间盘营养：影响营养素和代谢物浓度因素的综述
Thijs Grunhagen,Aboulfazl Shirazi-Adl,Jeremy C T Fairbank et al.
Thijs Grunhagen et al.
The biomechanical behavior of the intervertebral disk ultimately depends on the viability and activity of a small population of resident cells that make and maintain the disk's extracellular matrix. Nutrients that support these cells are su...