Skinomics, transcriptional profiling approaches to molecular and structural biology of epidermis [0.03%]
皮肤分子与结构生物学的转录组分析方法学:从基因到皮肤质地表型
Miroslav Blumenberg
Miroslav Blumenberg
Skinomics is a field of bioinformatics applied specifically to skin biology and, by extension, to dermatology. Skinomics has been expanding into extensive genome-wide association studies, eg, of psoriasis, proteomics, lipidomics, metabolomi...
Bioinformatic applications in psoriasis: genetics, transcriptomics, and microbiomics [0.03%]
银屑病的生物信息学应用：遗传、转录和微生物组学
Jason E Parad,Wilson Liao
Jason E Parad
Bioinformatics uses computationally intensive approaches to make sense of complex biological data sets. Here we review the role of bioinformatics in 3 areas of biology: genetics, transcriptomics, and microbiomics. Examples of bioinformatics...
Roberto Andres Novoa
Roberto Andres Novoa
Hilmy Shahbain,Chelsea Cooper,Pedram Gerami
Hilmy Shahbain
Certain subsets of melanocytic neoplasms are difficult to classify because of conflicting histologic features and the existence of a poorly defined intermediate grade of melanocytic tumors. The integration of molecular diagnostic informatio...
Molecular platforms utilized to detect BRAF V600E mutation in melanoma [0.03%]
用于检测黑色素瘤中BRAF V600E突变的分子平台
Jonathan L Curry,Carlos A Torres-Cabala,Michael T Tetzlaff et al.
Jonathan L Curry et al.
Metastatic melanoma (MM) is a deadly skin disease refractory to standard chemotherapy. Despite numerous clinical and pathological parameters derived to guide patient management, clinical outcomes in melanoma patients remain difficult to pre...
Update on the genetics of androgenetic alopecia, female pattern hair loss, and alopecia areata: implications for molecular diagnostic testing [0.03%]
雄激素性脱发、女性型脱发和斑秃的遗传学进展及其分子诊断意义
Pedram Yazdan
Pedram Yazdan
Androgenetic alopecia, female pattern hair loss, and alopecia areata are among the most common forms of nonscarring hair loss encountered in clinical practice. Although the exact pathogenesis of these forms of alopecia remains to be clarifi...
Melissa Pulitzer
Melissa Pulitzer
The association between viruses and skin cancer is increasingly recognized in a number of neoplasms, that is, cutaneous squamous cell carcinoma, Kaposi sarcoma, nasopharyngeal carcinoma, and Merkel cell carcinoma, as well as hematolymphoid ...
Polymerase chain reaction-based molecular diagnosis of cutaneous infections in dermatopathology [0.03%]
基于聚合酶链反应的皮肤病学分子诊断方法应用于皮肤感染检测
Brian L Swick
Brian L Swick
Conventional methods, including microscopy, culture, and serologic studies, are a mainstay in the diagnosis of cutaneous infection. However, owing to limitations associated with these techniques, such as low sensitivity for standard microsc...
Janyana M D Deonizio,Joan Guitart
Janyana M D Deonizio
The purpose of this review is to summarize the most important molecular techniques for the diagnosis of cutaneous lymphomas. When making a diagnosis, we are looking for the solid clinicopathological correlation. Molecular analysis includes ...
The role of molecular testing in the diagnosis of cutaneous soft tissue tumors [0.03%]
分子检测在皮肤软组织肿瘤诊断中的作用
Alison L Cheah,Steven D Billings
Alison L Cheah
A number of soft tissue tumors are characterized by recurring genetic abnormalities. The identification of these abnormalities has advanced our understanding of the biology of these tumors and has led to the development of molecular tests t...