Late-Onset Sepsis: Epidemiology, Microbiology, and Controversies in Practice [0.03%]
晚发性败血症：流行病学、微生物学和实践中的争议问题
Jessica E Ericson,Alexander G Agthe,Joern-Hendrik Weitkamp
Jessica E Ericson
Late-onset sepsis (LOS) is a common cause of neonatal morbidity and mortality. Causative pathogens vary by gestational age and geographic location. Preterm neonates in low-resource settings are at greatest risk and the majority of cases are...
Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care [0.03%]
昼夜节律、免疫调节和发生全身性炎症反应的风险：昼夜节律与新生儿护理
Shaon Sengupta,David F Smith,Bala S C Koritala
Shaon Sengupta
Circadian rhythms provide an anticipatory mechanism for organisms to adapt to environmental changes. Host response to infections is under robust circadian control. Most of the existing literature focuses on adults in epidemiologic and anima...
Machine Learning Models as Early Warning Systems for Neonatal Infection [0.03%]
机器学习模型在新生儿感染早期预警中的作用
Brynne A Sullivan,Robert W Grundmeier
Brynne A Sullivan
Neonatal infections pose a significant threat to the health of newborns. Associated morbidity and mortality risks underscore the urgency of prompt diagnosis and treatment with appropriate empiric antibiotics. Delay in treatment can be fatal...
Neonatal Early-Onset Sepsis: Epidemiology, Microbiology, and Controversies in Practice [0.03%]
新生儿早期感染性脓毒症：流行病学、微生物和实践中的争议问题
Dustin D Flannery,Veena Ramachandran,Stephanie J Schrag
Dustin D Flannery
Early-onset sepsis (EOS) remains a substantial contributor to neonatal morbidity and mortality. Continued epidemiologic surveillance of incidence, risk factors, and microbiology is paramount to developing new prevention strategies and optim...
Role of the Microbiome in Neonatal Infection: Pathogenesis and Implications for Management [0.03%]
新生儿感染中微生物组的作用：发病机制及管理意义
Carolyn McGann,Riley Phyu,Kyle Bittinger et al.
Carolyn McGann et al.
The human microbiome refers to the collective genome of microorganisms, including bacteria, fungi, and viruses residing on human body surfaces that are in contact with the environment. Together these communities protect against invasive inf...
Re-Thinking the Norms of Antibiotic Prescribing in the Neonatal Intensive Care Unit [0.03%]
NICU抗生素使用的再思考
Genevieve Pg Fung,Joseph Y Ting
Genevieve Pg Fung
Antibiotics are among the most commonly prescribed medications in neonatal care. Newborns are particularly vulnerable to severe infections and the adverse effects associated with inappropriate antibiotic use. Antibiotic stewardship programs...
Neonatal Cytomegalovirus Infection: Advocacy, Legislation, and Changing Practice [0.03%]
新生儿巨细胞病毒感染：呼吁、立法和改变实践
Ashley Stark,Chelsea M Crooks,Sallie R Permar et al.
Ashley Stark et al.
Cytomegalovirus (CMV) is the most common intrauterine infection. While only 10% to 15% of infants display symptoms at birth, 25% of infants with congenital CMV (cCMV) will develop sequelae such as sensorineural hearing loss and neurodevelop...
Alexandra K Medoro,Karen M Puopolo
Alexandra K Medoro
Transplacental transfer of maternal antibody in utero is a key component of neonatal immunity. This transfer of maternal antibody across the placenta provides temporary protection from bacterial and viral pathogens that threaten newborn hea...
Keeping Your Neonatal Intensive Care Unit Clean: The Hospital Environment as a Potential Source of Health Care-Associated Infections [0.03%]
保持新生儿重症监护病房的清洁：医院环境作为潜在的 healthcare-associated infections 发生源头
Judith A Guzman-Cottrill,Kristina A Bryant
Judith A Guzman-Cottrill
The patient's environment is an important (and often overlooked) source of pathogen exposure for patients in the neonatal intensive care unit (NICU) setting. Environmental surfaces in the NICU, including those frequently touched during the ...
Lucky Jain
Lucky Jain