Novel Approaches to the Treatment of Preterm White Matter Injury through Targeting Remyelination [0.03%]
针对早产儿脑白质损伤的少突胶质细胞靶向治疗新策略
Bridget E L Ostrem,Dawn Gano
Bridget E L Ostrem
Preterm white matter injury (WMI) is a common cause of cerebral palsy and cognitive disability after premature birth. Preterm WMI is caused by a differentiation arrest in the oligodendrocyte (OL) lineage, and a failure of myelination. As th...
Advances in Genetic Testing of Neurologically Abnormal Neonates in the Neonatal Intensive Care Unit [0.03%]
新生儿重症监护病房神经异常新生儿遗传学检测进展
William Burns,Darrah Haffner,Bimal P Chaudhari
William Burns
Recent advances in cost and speed with which genome sequencing can be achieved have changed the approach to genetic testing in neonatal intensive care units (NICUs). In this article, we review the impact of these changes on the genetic eval...
Ekta G Shah,Jeffrey J Neil,Christopher D Smyser
Ekta G Shah
Neuroimaging has a vital role in assessing the neonatal neuroaxis in many different clinical contexts and in stratifying risk for neurodevelopmental differences. Advances in hardware and computational techniques across modalities have burge...
Updates in Neonatal Neuromonitoring: Electroencephalography, Near-Infrared Spectroscopy, and Transcranial Doppler in the Neonatal Intensive Care Unit [0.03%]
新生儿神经监测的更新：NICU中的脑电图，近红外光谱和经颅多普勒检测技术
Giulia M Benedetti,Zachary A Vesoulis
Giulia M Benedetti
This article discusses advanced neuromonitoring techniques for neonates in intensive care, focusing on electroencephalography, near-infrared spectroscopy, and transcranial Doppler ultrasound. These noninvasive methods provide real-time data...
Fetal Consultation, Delivery Planning, and Perinatal Transition for Congenital Neurologic Disorders [0.03%]
先天性神经病理性疾病的胎儿咨询、分娩计划和围产期过渡
Laura E Vernon
Laura E Vernon
Anomalies of the central nervous system (CNS) are a frequent referral indication for perinatal evaluation and management through fetal neurology consultation. This multidisciplinary field is evolving quickly to provide adequate care through...
Lucky Jain
Lucky Jain
Perinatal and Neonatal Infections: Core Concepts, Emerging Issues, and Future Perspectives [0.03%]
围产期与新生儿感染：核心概念、新出现的问题及未来展望
Sagori Mukhopadhyay,Karen M Puopolo
Sagori Mukhopadhyay
Noelle Younge,Ravi M Patel
Noelle Younge
Probiotic use has increased in preterm infants and may reduce the risk of necrotizing enterocolitis. Probiotic-associated infection is a concern for infants receiving probiotic supplementation in the neonatal intensive care unit, as highlig...
Pharmacokinetic and Pharmacodynamic Approaches to Optimize Antibiotic Use in Neonates [0.03%]
用于优化新生儿抗生素使用的药代动力学和药效学方法
Sarah A Coggins,Rachel G Greenberg
Sarah A Coggins
Newborn infants (particularly those born preterm) are frequently exposed to empiric antibiotics at birth, and antibiotics are among the most commonly prescribed medications in neonatal intensive care units. Challenges in optimizing neonatal...
Neonatal Invasive Fungal Infections: Epidemiology, Microbiology, and Controversies in Practice [0.03%]
新生儿侵袭性真菌感染：流行病学、微生物和实践中的争议
David A Kaufman,Sagori Mukhopadhyay
David A Kaufman
As neonatology has moved to caring for infants of lower gestational ages, prevention, prompt diagnosis, and treatment of invasive fungal infections have contributed to the improved neonatal outcomes. Standardized care should include an infe...