Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach [0.03%]
新生儿肺动脉高压的氧合目标：“精准医学”个体化方法
Satyan Lakshminrusimha,Steven H Abman
Satyan Lakshminrusimha
Oxygen is a specific pulmonary vasodilator. Hypoxemia causes pulmonary vasoconstriction, and normoxia leads to pulmonary vasodilation. However, hyperoxia does not enhance pulmonary vasodilation but causes oxidative stress. There are no clin...
Targeted Neonatal Echocardiography in the Management of Neonatal Pulmonary Hypertension [0.03%]
新生儿肺动脉高压管理中的目标导向性新生儿超声心动图检查
Stephanie M Boyd,Martin Kluckow,Patrick J McNamara
Stephanie M Boyd
Pulmonary hypertension (PH) in neonates, originating from a range of disease states with heterogeneous underlying pathophysiology, is associated with significant morbidity and mortality. Although the final common pathway is a state of high ...
Emily S Stieren,Deepika Sankaran,Satyan Lakshminrusimha et al.
Emily S Stieren et al.
Long-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developm...
Randomized Controlled Trials of Pulmonary Vasodilator Therapy Adjunctive to Inhaled Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn: A Systematic Review [0.03%]
新生儿持续性肺动脉高压联合吸入一氧化氮的肺血管舒张治疗的随机对照试验：系统回顾
Kristen Coletti,K Taylor Wild,Elizabeth E Foglia et al.
Kristen Coletti et al.
Inhaled nitric oxide (iNO) is a pulmonary vasodilator considered standard of care to treat persistent pulmonary hypertension of the newborn. However, not all infants respond to iNO. The authors performed a systematic review to examine metho...
Etiology, Diagnosis and Management of Persistent Pulmonary Hypertension of the Newborn in Resource-limited Settings [0.03%]
资源匮乏地区新生儿持续性肺动脉高压的病源、诊断和处理方法
Prathik Bandiya,Rajeshwari Madappa,Ajay Raghav Joshi
Prathik Bandiya
Persistent Pulmonary Hypertension of the Newborn (PPHN) is more common in Low and middle income countries (LMICs) due to high incidence of sepsis, perinatal asphyxia and meconium aspiration syndrome. Presence of hypoxic respiratory faillure...
Olivier Danhaive,Csaba Galambos,Satyan Lakshminrusimha et al.
Olivier Danhaive et al.
Diverse genetic developmental lung diseases can present in the neonatal period with hypoxemic respiratory failure, often associated with with pulmonary hypertension. Intractable hypoxemia and lack of sustained response to medical management...
Pathogenesis and Physiologic Mechanisms of Neonatal Pulmonary Hypertension: Preclinical Studies [0.03%]
新生儿肺动脉高压的发病和生理机制：临床前研究
Karen C Young,Augusto F Schmidt,April W Tan et al.
Karen C Young et al.
Neonatal pulmonary hypertension (PH) is a devastating disorder of the pulmonary vasculature characterized by elevated pulmonary vascular resistance and mean pulmonary arterial pressure. Occurring predominantly because of maldevelopment or m...
Pulmonary Hypertension in Established Bronchopulmonary Dysplasia: Physiologic Approaches to Clinical Care [0.03%]
支气管肺发育不良已发生肺动脉高压的生理学治疗措施探讨
Steven H Abman,Satyan Lakshminrusimha
Steven H Abman
Preterm infants with bronchopulmonary dysplasia (BPD) are prone to develop pulmonary hypertension (PH). Strong laboratory and clinical data suggest that antenatal factors, such as preeclampsia, chorioamnionitis, oligohydramnios, and placent...
Srinivasan Mani,Hussnain Mirza,James Ziegler et al.
Srinivasan Mani et al.
Pulmonary hypertension (PH) in preterm neonates has multifactorial pathogenesis with unique characteristics. Premature surfactant-deficient lungs are injured following exposure to positive pressure ventilation and high oxygen concentrations...
Congenital Diaphragmatic Hernia: Pulmonary Hypertension and Pulmonary Vascular Disease [0.03%]
先天性膈疝：肺动脉高压和肺血管疾病
Shiran S Moore,Roberta L Keller,Gabriel Altit
Shiran S Moore
This review provides a comprehensive summary of the current understanding of pulmonary hypertension (PH) in congenital diaphragmatic hernia, outlining the underlying pathophysiologic mechanisms, methods for assessing PH severity, optimal ma...