An Efficient Dynamic Data Structure for Haplotype Matching and Compression on Biobank-Scale Data [0.03%]
高效处理生物库规模数据单倍型匹配和压缩的动态数据结构
Pramesh Shakya,Ahsan Sanaullah,Degui Zhi et al.
Pramesh Shakya et al.
Advanced genotyping technology has made it feasible for large numbers of individuals to be genotyped resulting in many biobanks across the world. These biobanks are an excellent resource to study haplotype matching at a large scale. Durbin'...
Xiao Liang,Lenwood S Heath
Xiao Liang
Cancer genes, including oncogenes and tumor suppressor genes, are crucial subjects of study in human health. With advancements in nonhuman primate genome research, recent investigations have started to explore the relationship between human...
mcRigor: A Statistical Software Package for Evaluating and Optimizing Metacell Partitioning in Single-Cell Data Analysis [0.03%]
mcRigor：一种用于评估和优化单细胞数据分析中元细胞划分的统计软件包
Pan Liu,Jingyi Jessica Li
Pan Liu
Metacell partitioning is a common preprocessing step in single-cell data analysis, used to reduce sparsity by aggregating similar cells. However, existing metacell partitioning algorithms may inadvertently group heterogeneous cells, potenti...
ClusterDE: A Statistical Software Package for Removing Double-Dipping Bias in Post-Clustering Differential Expression Analysis [0.03%]
ClusterDE：一种用于去除聚类后差异表达分析中的双重利用偏差的统计软件包
Christy Lee,Dongyuan Song,Siqi Chen et al.
Christy Lee et al.
Typical pipelines for single-cell and spatial transcriptomics involve clustering cells or spatial spots, followed by post-clustering differential expression (DE) analysis to identify marker genes for annotating clusters as cell types or spa...
BCtypeFinder: A Semi-Supervised Model with Domain Adaptation for Breast Cancer Subtyping Using DNA Methylation Profiles [0.03%]
基于DNA甲基化谱的乳腺癌亚型分类半监督模型BCtypeFinder及其领域自适应研究
Joung Min Choi,Liqing Zhang
Joung Min Choi
Accurate breast cancer subtype prediction is critical for precise diagnosis, treatment planning, and prognosis evaluation. Recent studies highlight the important role of epigenetic modifications in breast tumor, especially the potential of ...
Donghui Son,Jaejik Kim
Donghui Son
Dynamic systems encompass a broad class of mathematical models used to describe the behavior of complex networks or systems over time. One of the most common approaches to modeling such dynamics is through a set of ordinary differential equ...
A Biologically Informed and Efficient DNA Sequence Learner for Predicting Functional Genomics Events [0.03%]
一种生物信息丰富的DNA序列学习器，用于预测功能基因组事件
Mohammad Shiri,Jiangwen Sun
Mohammad Shiri
Elucidating the functional mechanisms underlying most associations between phenomes and genomes uncovered by genome-wide association studies remains a challenging problem. Deep neural networks that excel in feature learning from sequential ...
CerviNet: A Novel Approach for Cervical Cancer Classification Using Pap-Smear Images [0.03%]
基于液基薄层细胞学技术的宫颈癌分类的新方法CerviNet
Ashfaque Khowaja,Zou Beiji,Xiaoyan Kui
Ashfaque Khowaja
Cervical cancer is the fourth most common disease among women worldwide, and pap smear images are used as a primary diagnostic technique to detect precancerous and cancerous abnormalities in the cervix, vagina, and vulva. Deep learning algo...
Group-Penalized Exponential Tilt Model for Identification of Differentially Methylated Genes in Epigenetic Association Studies [0.03%]
分组惩罚指数偏移模型在表观基因组关联研究中的应用
Dan Huang,Hyerim Park,Hokeun Sun
Dan Huang
DNA methylation is a representative epigenetic change that occurs in our body and plays an essential role in regulating gene expression as well as in cancer progression. Identification of differentially methylated genes between two biologic...