Simple and Thorough Detection of Related Sequences with Position-Varying Probabilities of Substitutions, Insertions, and Deletions [0.03%]
基于 substitution、insertion 和 deletion 的位置变异概率的简单而彻底的 related sequence 检测方法
Martin C Frith,Patrick Boppert,Patrick Styll et al.
Martin C Frith et al.
One way to understand biology is by finding genetic sequences that are related to each other. Often, a family of related sequences has position-varying probabilities of substitutions, insertions, and deletions: we can use these to find dist...
A Cross-Order Comparative Genomics Analysis of Insect Innate Immunity Suggests Niche-Specific Adaptation [0.03%]
横跨等级的昆虫先天免疫组学分析表明了生态位特异性适应
Triveni Shelke,Vanika Gupta,Ishaan Gupta
Triveni Shelke
Insects thrive in highly diverse environmental niches, exposing them to varying pathogens. This complex interaction has led to the development of a variety of defense mechanisms collectively termed as innate immunity. Innate immunity is the...
MEditome: Computational Detection of RNA Edit Sites Using de Novo Assembly in Microbiomes [0.03%]
MEditome：使用从头组装计算检测微生物组中的RNA编辑位点
Arpit Mehta,Vitalii Stebliankin,Kalai Mathee et al.
Arpit Mehta et al.
RNA editing is a post-transcriptional modification that alters single-nucleotide sites within RNA strands, thus diversifying transcriptomes and proteomes and modulating gene expression. While better characterized in eukaryotes and in a few ...
Gene Network Enrichment Analysis and Its Application to Explore Enriched Immune Disease Pathways for Gene Network of Acute Myeloid Leukemia Cell Lines [0.03%]
基因网络富集分析及其在探索急性髓系白血病细胞系的免疫疾病通路中的应用
Heewon Park,Satoru Miyano
Heewon Park
Recent advances in gene network analysis have improved our understanding of complex disease mechanisms; however, interpreting estimated gene networks remains challenging. Existing methods for pathway enrichment analysis focus on gene sets a...
Beyond Synteny: A Scalable Phylogenomics Method for Whole-Genome Duplication Detection [0.03%]
超越共线性：一种用于全基因组复制检测的大规模生物信息学方法
Reza Kalhor,Manuel Lafond,Celine Scornavacca
Reza Kalhor
Gene duplication is a fundamental driver of species adaptation and the evolution of new functions, making the reconstruction of historical duplication events crucial for understanding evolutionary processes. Whole-genome duplications (WGDs)...
Stability Analysis of Age-Structured Stochastic Delayed Population-Toxicant Model with Lévy Noise [0.03%]
Levy噪声下年龄结构的随机时滞种群毒物模型的稳定性分析
Yanyan Du,Zong Wang
Yanyan Du
In this article, we develop a new age-structured stochastic delayed toxicant-population model with Lévy noise. Some novel criteria for the existence of a global positive solution and the mean square h-stability of the addressed model are g...
Joyanta Basak,Nidhibahen Shah,Kenneth Haase et al.
Joyanta Basak et al.
The Jaro and Jaro-Winkler similarity measures are fundamental tools for character-based string comparison, with widespread use in applications such as record linkage, entity resolution, and natural language processing. Although their accura...
Reconstructing Ancestral Non-Coding RNAs of Multiple Families Using Sequence and Structural Information with Tree Decomposition [0.03%]
基于序列和结构信息利用树分解重构多家族祖先非编码RNA
Songdi Hu,Vladimir Reinharz,Olivier Tremblay-Savard
Songdi Hu
The reconstruction of ancestral non-coding RNA (ncRNA) sequences is particularly challenging due to the main conservation forces being applied to the structure, rather than the sequence. Naively trying to preserve the structure during the r...
PMScanR: An R Package for the Large-Scale Identification, Analysis, and Visualization of Protein Motifs [0.03%]
PMScanR：一个用于大规模鉴定、分析和可视化蛋白质基序的R软件包
Jan P Jastrzebski,Monika Gawronska,Wiktor Babis et al.
Jan P Jastrzebski et al.
Proteins play a crucial role in biological processes, with their functions closely related to structure. Protein functions are often associated with specific motifs, which are short amino acid sequences exhibiting particular patterns. Most ...
DP-OTG: A Feature-Free Deep Learning Model for Accurate Prediction of Human O-Linked Threonine Glycosylation Sites [0.03%]
一种无特征的人类O连接苏糖酸糖基化位点的深度学习预测模型_dp-otg
Thi-Xuan Tran,Nguyen-Quoc-Khanh Le,Duc-Hau Le et al.
Thi-Xuan Tran et al.
Protein O-linked threonine glycosylation (OTG) is a crucial post-translational modification in eukaryotic species, playing a vital role in diverse biological processes. In humans, dysregulation of OTG has been associated with serious diseas...