Chloe Opper,Megan Bannon,Ashley L Devonshire
Chloe Opper
Immunoglobulin E-mediated food allergies affect millions of patients worldwide. Understanding food allergies, other food-related clinical phenotypes, and clinically available diagnostic testing options can help providers care for impacted p...
Maria A Forero Molina,Yuri E Kram,Bruce J Lanser
Maria A Forero Molina
Food allergy, now widely recognized since the mid-twentieth century, is an immune reaction to specific proteins, often involving immunoglobulin E antibodies. They can cause symptoms ranging from mild discomfort to life-threatening responses...
Jessica W Hui-Beckman,Byung-Eui Kim
Jessica W Hui-Beckman
As the incidence of allergic conditions increases, industrialization and environmental exposures are thought to contribute to the rise in atopy, as genetics alone cannot explain this. Various prenatal and postnasal exposures contribute to e...
Diagnostic Tools, Biomarkers, and Noninfectious Treatment Considerations for Genetic Disorders of Immunity [0.03%]
遗传性免疫异常的诊断工具、生物标志物及非感染治疗考虑因素
Jessica Galant-Swafford,Cullen Dutmer
Jessica Galant-Swafford
Therapeutic Approaches for Periodic Fever Syndromes and Autoinflammatory Disorders [0.03%]
周期性发热综合征和自炎症性疾病的治疗策略
Angel A Herrera Guerra,Victoria R Dimitriades
Angel A Herrera Guerra
As immunologists, we evaluate patients with a large spectrum of disorders, which include impaired immunity, autoimmunity, and autoinflammatory features. Recent discoveries in inflammatory pathways have elucidated disease pathogenesis and al...
Non-Infectious Complications of Chronic Granulomatous Disease: Knowledge Gaps & Novel Treatment Considerations [0.03%]
慢性肉芽肿病的非感染性并发症：知识差距及新型治疗考量
Christopher McKinney,Daniel Ambruso
Christopher McKinney
Chronic granulomatous disease (CGD) is a rare primary phagocytic immunodeficiency characterized by recurrent infections due to impaired NADPH oxidase activity. Balancing the need for additional immune suppression with the risk of infection ...
Navigating the Complexities of Common Variable Immunodeficiency Enteropathy: From Established Therapies to Emerging Interventions [0.03%]
共变量免疫缺陷肠病的复杂性：从 established therapies 到新兴干预措施
Joud Hajjar,Ahmed Rehman,Ahmed Hamdi et al.
Joud Hajjar et al.
Common Variable Immunodeficiency (CVID) is a prevalent primary immunodeficiency in adults, marked by low immunoglobulin levels and recurrent infections. This review examines the gastrointestinal complications of CVID, including both infecti...
Updates in the Understanding of Immunoglobulin Replacement Therapy in Primary Immune Deficiency Disorders: Function, Composition, and Role in Reconstitution and Immunomodulation [0.03%]
原发性免疫缺陷病免疫球蛋白替代治疗研究进展：功能、组分和重建及免疫调节作用
Talal Mousallem,Geoffrey Hall,Alice Pan et al.
Talal Mousallem et al.
Clinical indications for immunoglobulin therapy can be broadly classified into replacement therapy for immunodeficiencies, immunomodulatory treatment of inflammatory conditions, and hyperimmune therapy against specific infectious agents. Wh...
William Bracamonte-Baran,Sang T Kim
William Bracamonte-Baran
With their groundbreaking clinical responses, immune checkpoint inhibitors (ICIs) have ushered in a new chapter in cancer therapeutics. However, they are often associated with life-threatening or organ-threatening autoimmune/autoinflammator...
Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders [0.03%]
免疫缺陷和其他免疫疾病的临床细胞计量学的最新研究进展
Amir A Sadighi Akha,Krisztián Csomós,Boglárka Ujházi et al.
Amir A Sadighi Akha et al.
Primary immunodeficiencies were initially identified on the basis of recurrent, severe or unusual infections. Subsequently, it was noted that these diseases can also manifest with autoimmunity, autoinflammation, allergy, lymphoproliferation...