GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression [0.03%]
GDF-15预测上皮样血管内皮瘤的侵袭性并通过抑制ATF4/ATF5由西罗莫司下调
Silvia Stacchiotti,Silvia Martini,Sandro Pasquali et al.
Silvia Stacchiotti et al.
Purpose: Epithelioid hemangioendothelioma (EHE), an ultra-rare sarcoma, poses therapeutic challenges because of limited efficacy of conventional chemotherapy in advanced cases, necessitating exploration of new treatment a...
High Mechanical Conditioning by Tumor Extracellular Matrix Stiffness Is a Predictive Biomarker for Antifibrotic Therapy in HER2-Negative Breast Cancer [0.03%]
肿瘤细胞外基质刚度高机械调节是HER2阴性乳腺癌抗纤维化治疗的预测生物标志物
Miguel Quintela-Fandino,Begoña Bermejo,Esther Zamora et al.
Miguel Quintela-Fandino et al.
Purpose: Tumor progression has been linked to stiffening of the extracellular matrix caused by fibrosis. Cancer cells can be mechanically conditioned by stiff extracellular matrix, exhibiting a 1,004-gene signature [mecha...
Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer [0.03%]
胰腺癌经典型和基底型转录亚型的临床和基因组特征
Harshabad Singh,Joanne Xiu,Kevin S Kapner et al.
Harshabad Singh et al.
Purpose: Transcriptional profiling of pancreatic cancers has defined two main transcriptional subtypes: classical and basal. Initial data suggest shorter survival for patients with basal tumors and differing treatment sen...
Plasma ctDNA as a Treatment Response Biomarker in Metastatic Cancers: Evaluation by the RECIST Working Group [0.03%]
RECIST工作组评估的血浆ctDNA作为转移性癌症治疗反应标志物的效果
Alexander W Wyatt,Saskia Litiere,Francois-Clément Bidard et al.
Alexander W Wyatt et al.
Early indicators of metastatic cancer response to therapy are important for evaluating new drugs and stopping ineffective treatment. The RECIST guidelines based on repeat cancer imaging are widely adopted in clinical trials, are used to ide...
MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor [0.03%]
在NF1缺陷型恶性外周神经鞘瘤中，MEK抑制剂导致PDGFR通路上调并使肿瘤对RAF二聚体抑制剂敏感
Miguel A Miranda-Román,Cindy J Lee,Eve Fishinevich et al.
Miguel A Miranda-Román et al.
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft-tissue sarcoma with a high propensity to metastasize and extremely limited treatment options. Loss of the RAS-GAP NF1 leads t...
Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer [0.03%]
雄激素剥夺治疗驱动局部前列腺癌的免疫表型发生变化
Matthew C Dallos,Aleksandar Z Obradovic,Patrick McCann et al.
Matthew C Dallos et al.
Purpose: Androgen deprivation therapy (ADT) remains the backbone of prostate cancer treatment. Beyond the suppression of testosterone and tumor cell growth, emerging evidence suggests that ADT also modulates the immune tu...
Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer [0.03%]
组蛋白H3K27和H3K4三甲基化介导的表观基因重编程是BRAF V600E突变型结直肠癌DNA去甲基化抵抗机制
Hey Min Lee,Ajay Kumar Saw,Van K Morris et al.
Hey Min Lee et al.
Purpose: BRAFV600E-mutated colorectal cancer exhibits a strong correlation with DNA hypermethylation, suggesting that this subgroup of tumors presents unique epigenomic phenotypes. Nonetheless, 5-azacitidine, which inhibi...
Hepatocellular Carcinoma Immune Microenvironment Analysis: A Comprehensive Assessment with Computational and Classical Pathology [0.03%]
肝细胞癌免疫微环境分析：计算与经典病理的全面评估
Caner Ercan,Salvatore Lorenzo Renne,Luca Di Tommaso et al.
Caner Ercan et al.
Purpose: The spatial variability and clinical relevance of the tumor immune microenvironment (TIME) are still poorly understood for hepatocellular carcinoma (HCC). In this study, we aim to develop a deep learning (DL)-bas...
The Epstein-Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction [0.03%]
与鼻咽癌相关的一种EB病毒核抗原1变异体界定了血清学风险预测的序列标准
Benjamin E Warner,Japan Patel,Renwei Wang et al.
Benjamin E Warner et al.
Purpose: Antibodies to select Epstein-Barr virus proteins can diagnose early-stage nasopharyngeal carcinoma (NPC). We have previously shown that IgA against Epstein-Barr virus nuclear antigen 1 (EBNA1) can predict inciden...
TAK1 Promotes an Immunosuppressive Tumor Microenvironment through Cancer-Associated Fibroblast Phenotypic Conversion in Pancreatic Ductal Adenocarcinoma [0.03%]
TAK1通过癌症相关成纤维细胞表型转换促进胰腺导管腺癌免疫抑制性肿瘤微环境
Nan Sheng,Koji Shindo,Kenoki Ohuchida et al.
Nan Sheng et al.
Purpose: We aim to clarify the precise function of TGFβ1-activated kinase 1 (TAK1) in cancer-associated fibroblasts (CAF) within human pancreatic ductal adenocarcinoma (PDAC) by investigating its role in cytokine-mediate...