Reduced Platelet Activation in Triple-Negative Essential Thrombocythemia Compared with JAK2V617F-Mutated Essential Thrombocythemia [0.03%]
与JAK2V617F突变原发性血小板增多症相比，三阴性原发性血小板增多症患者血小板活化减弱
Huan Dong,Jia Chen,Jing Zhang et al.
Huan Dong et al.
Purpose: Triple-negative (TN) essential thrombocytopenia (ET) is characterized by the absence of driver mutations while retaining histologic and phenotypic characteristics sufficient for an ET diagnosis. Our understanding...
Characterization of FGFR Alterations and Activation in Patients with High-Risk Non-Muscle-Invasive Bladder Cancer [0.03%]
高危非肌层浸润性膀胱癌患者中FGFR异常及活化的特征分析
Joel R Eisner,Florus C de Jong,Yoichiro Shibata et al.
Joel R Eisner et al.
Purpose: The Genomic Analysis of High-Risk Non-Muscle-Invasive Bladder Cancer (GARNER) study investigated FGFR alteration (ALT) frequency and the clinical outcome relationship with Bacillus Calmette-Guérin (BCG) treatmen...
Derk Jan A de Groot,Marjolijn N Lub-de Hooge,Tom van Meerten et al.
Derk Jan A de Groot et al.
Current immunotherapies have brought major progress in cancer treatments, but not all patients benefit. Therefore, insight into reasons for treatment failure and optimal biomarkers for patient selection are warranted. Current approved bioma...
The Tumor Immune Microenvironment Drives Survival Outcomes and Therapeutic Response in an Integrated Molecular Analysis of Gastric Adenocarcinoma [0.03%]
整合型分子分析在胃腺癌中的应用：肿瘤免疫微环境决定预后及治疗反应
Daniel Skubleny,Kieran Purich,David R McLean et al.
Daniel Skubleny et al.
Purpose: We performed an integrated analysis of molecular classification systems proposed by The Cancer Genome Atlas (TCGA), the Asian Cancer Research Group (ACRG), and the tumor microenvironment (TME) score to identify w...
Combinations of HDAC Inhibitor and PPAR Agonist Induce Ferroptosis of Leukemic Stem Cell-like Cells in Acute Myeloid Leukemia [0.03%]
HDAC抑制剂与PPAR激动剂联合诱导急性髓系白血病类白血病干细胞的铁死亡
Hui Zhou,Dongmei Qin,Chendi Xie et al.
Hui Zhou et al.
Purpose: Leukemic stem cells (LSC) are responsible for leukemia initiation, relapse, and therapeutic resistance. Therefore, the development of novel therapeutic approaches targeting LSCs is urgently needed for patients wi...
A Novel Human SDHA-Knockout Cell Line Model for the Functional Analysis of Clinically Relevant SDHA Variants [0.03%]
一种新颖的人类SDHA敲除细胞系模型用于临床相关SDHA变异功能分析
Jason D Kent,Lillian R Klug,Michael C Heinrich
Jason D Kent
Purpose: SDHA mutations are the most common cause of succinate dehydrogenase (SDH)-deficient GIST. Enhanced cancer surveillance of individuals carrying a known pathogenic germline SDHA mutation has the potential to detect...
Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors [0.03%]
利用PARP抑制剂靶向CDK12缺陷型前列腺癌的合成致死性
Jonathan Chou,Troy M Robinson,Emily A Egusa et al.
Jonathan Chou et al.
Purpose: The cyclin-dependent kinase (CDK), CDK12, is mutated or amplified in multiple cancers. We previously described a subtype of prostate cancer characterized predominantly by frameshift, loss-of-function mutations in...
Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers [0.03%]
AZD6422的临床前评估：一种针对胃癌、胰腺癌和食管癌CLDN18.2的装甲嵌合抗原受体T细胞疗法
Allison M Barrett,Zachary T Britton,Rosa A Carrasco et al.
Allison M Barrett et al.
Purpose: Claudin 18.2 (CLDN18.2) is a surface membrane protein that is crucial for maintaining tight junctions in gastric mucosal cells and is highly expressed in gastric, esophageal, and pancreatic cancers. Thus, CLDN18....
Multidimensional Immunotyping of Human NF1-Associated Peripheral Nerve Sheath Tumors Uncovers Tumor-Associated Macrophages as Key Drivers of Immune Evasion in the Tumor Microenvironment [0.03%]
多维度免疫分型揭示肿瘤相关巨噬细胞是NF1外周神经鞘瘤微环境中的关键逃逸机制
Lindy Zhang,Alexandre Maalouf,Stavriani C Makri et al.
Lindy Zhang et al.
Purpose: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas and the leading cause of mortality in individuals with neurofibromatosis type 1 (NF1). Despite many clinical trials, outcomes f...
Update on Surveillance for Wilms Tumor and Hepatoblastoma in Beckwith-Wiedemann Syndrome and Other Predisposition Syndromes [0.03%]
贝克威思-威德曼综合征及其他易感征的肾母细胞瘤和肝母细胞瘤监测进展
Jennifer M Kalish,Kerri D Becktell,Gaëlle Bougeard et al.
Jennifer M Kalish et al.
Wilms tumors are commonly associated with predisposition syndromes, many but not all of which include overgrowth. Several of these syndromes also include a risk of other embryonal malignancies-particularly hepatoblastoma. Guidelines for sur...