Old clots, new questions - the anticoagulation saga continues in chronic thromboembolic pulmonary hypertension [0.03%]
旧栓新问-抗凝治疗在慢性血栓栓塞性肺动脉高压中继续书写传奇
Hakim Ghani,Joanna Pepke-Zaba
Hakim Ghani
Multimodal Molecular Testing Provides Prognostic Value for Heart Transplant Recipients [0.03%]
多模态分子检测可为心脏移植受者提供预后价值
Jeff Teuteberg,Snehal Patel,David A Baran et al.
Jeff Teuteberg et al.
Background: Multimodal molecular testing with gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) is increasingly used for rejection surveillance, but less is known about their joint ability to pred...
Results of the MACiTEPH study of macitentan for the treatment of inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension [0.03%]
马西替坦治疗不可手术的或顽固/复发性慢性血栓栓塞性肺动脉高压患者的MACiTEPH研究结果
David P Jenkins,Sofija Cerovic,Dénes Csonka et al.
David P Jenkins et al.
Background: In a phase 2 study of inoperable chronic thromboembolic pulmonary hypertension (CTEPH), macitentan 10 mg improved hemodynamics and exercise capacity. ...
Enhancement of suppressive function of Ly49+ CD8+ T cells in allogeneic immunity by CD80/86-CD28 blockade in mouse [0.03%]
小鼠异体免疫中CD80/86-CD28阻断增强Ly49阳性CD8阳性T细胞的抑制功能
Koji Tokushige,Yin Enzhi,Kyoko Tsuji-Yogo et al.
Koji Tokushige et al.
Background: Ly49⁺ CD8⁺ T cells restricted by Qa-1 or major histocompatibility complex (MHC)/peptide can function as immune suppressors in autoimmune diseases and chronic activation-associated tissue damage. In organ tra...
Fifty-Year Pediatric Heart Transplant Outcomes: A Pediatric-Adult Center Linked Analysis [0.03%]
50年儿童心脏移植随访结果：儿科和成人联合中心的分析
Seth A Hollander,Stephanie Hsiao,Anubodh S Varshney et al.
Seth A Hollander et al.
Purpose: Long-term outcomes after pediatric heart transplant (pHT) are rarely reported owing to young programs and loss of follow-up after transition to adult care. We leveraged our program age, center volume, and linked ...
Sex-biased immune rewiring may underlie reduced risk for cardiac allograft vasculopathy in females following heart transplantation [0.03%]
性别偏倚的免疫重塑可能是心脏移植后女性冠状动脉移植物血管病风险降低的原因
Kyle Saysana,Nelson Chow,Shi Huang et al.
Kyle Saysana et al.
Background: Uncovering sex-based differences in immunologic outcomes following heart transplantation (HT) can inform risk stratification and precision immunosuppressive strategies. However, granular clinical-translational...
The NHLBI Lung Transplant Consortium 2025 Steering Committee Report: Strategies to Maximize the Use of the Consortium for Advancing Lung Transplantation [0.03%]
国家心脏、肺和血液研究所肺移植联盟2025指导委员会报告：最大限度地利用联盟推进肺移植的战略
Megan Neely,Emmanuel Mongodin,Bryan A Whitson et al.
Megan Neely et al.
The Lung Transplant Consortium (LTC) sponsored by the National Heart, Lung, and Blood Institute (NHLBI) is a 20-center collaboration among lung transplant programs in North America conducting both smaller multicenter projects and one consor...
Rethinking Heart Transplant Allocation: Aligning Urgency, Equity, and Outcomes [0.03%]
重新思考心脏移植分配：兼顾紧急程度、公平性和效果
Vanessa Blumer,Michelle M Kittleson,Kiran K Khush et al.
Vanessa Blumer et al.
Since the implementation of the new allocation system for heart transplantation in 2018, various unintended consequences have emerged. In response, a recent policy amendment was proposed that took effect in September 2025 requiring transpla...
Pediatric Heart Transplantation after Circulatory Death: Hope through HOPE [0.03%]
HOPE儿童供心移植项目让DCD捐献者成为可能
Jens Böhmer,Göran Dellgren
Jens Böhmer
Invited Response Letter [0.03%]
答谢函
John Trahanas,Awab Ahmad,Swaroop Bommareddi et al.
John Trahanas et al.