David A Mankoff
David A Mankoff
Rodney J Hicks
Rodney J Hicks
After diagnosis and staging of cancer, the most important process in modern oncology is assessment of therapeutic response. Timely identification of patients with poor response may allow introduction of alternative therapies, sparing patien...
FDG-PET to Measure Response to Targeted Therapy: The Example of Gastrointestinal Stromal Tumor and Imatinib Mesylate (Gleevec) [0.03%]
FDG-PET测定靶向治疗的效果:胃肠道间质瘤和甲磺酸伊马替尼(Gleevec)的实例分析
Annick D Van den Abbeele,Mehmet Ertuk
Annick D Van den Abbeele
Imaging has played a major role in the evaluation of molecular targeted therapies in patients with gastrointestinal stromal tumors. FDG-PET has been instrumental in the evaluation of the tyrosine kinase inhibitors used to treat this disease...
Lale Kostakoglu
Lale Kostakoglu
This article discusses evaluating response after and during therapy in various settings and for the types of cancers for which ample evidence demonstrates that PET imaging with flourodeoxyglucose provides a valuable surrogate for response t...
Lale Kostakoglu
Lale Kostakoglu
In this article, the discussions about concepts involved in anticancer therapy, including cell death pathways and the variables that guide clinical management, such as intents and types of anticancer therapy regimens and modalities, are a p...
Adriaan A Lammertsma,Ronald Boellaard,Otto S Hoekstra
Adriaan A Lammertsma
Monitoring response to anticancer therapy requires a (semi)quantitative PET approach. In this review, several instrumentation and analysis issues that have an impact on quantification are discussed. These issues are divided into the followi...
Lalitha K Shankar
Lalitha K Shankar
A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. In vitro biomarkers include histopathol...
Todd M Blodgett,Melanie B Fukui
Todd M Blodgett
Regiane S de Andrade,Dwight E Heron
Regiane S de Andrade
Innovative approaches have been incorporated to radiation therapy over the last decades. The technologic advances, such as intensity modulated radiation therapy and image guided radiation have resulted in a modern era for this oncologic mod...
Erik S Mittra,Andrei Iagaru,Andrew Quon et al.
Erik S Mittra et al.
The utility of 18-F-fluorodeoxyglucose-positron emission tomography (PET) and PET/CT for the evaluation of skull base tumors is incompletely investigated, as a limited number of studies specifically focus on this region with regard to PET i...