Andrew D Krystal
Andrew D Krystal
Drug-related Sleep Stage Changes: Functional Significance and Clinical Relevance [0.03%]
药物引起的睡眠阶段变化:功能意义与临床相关性
Timothy Roehrs,Thomas Roth
Timothy Roehrs
Pepe J Hernandez,Ted Abel
Pepe J Hernandez
The electrophysiological properties of the sleeping brain profoundly influence memory function in various species, yet the molecular nature by which sleep and memory interact remains unclear. We summarize work that has established the cAMP-...
Christopher J Watson,Helen A Baghdoyan,Ralph Lydic
Christopher J Watson
The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs but for no drug is the mechanism of action completely understood. All available sedative/hypnoti...
Ehren R Dodson,Phyllis C Zee
Ehren R Dodson
The sleep-wake cycle is regulated by the interaction of endogenous circadian and homeostatic processes. The circadian system provides timing information for most physiological rhythms, including the sleep and wake cycle. In addition, the ce...
BIOLOGICAL TIMEKEEPING [0.03%]
生物学的时光流转
Martha U Gillette,Sabra M Abbott
Martha U Gillette
Omer Ahmed,Sairam Parthasarathy
Omer Ahmed
PURPOSE OF REVIEW: Positive airway pressure therapy (PAP) is commonly prescribed treatment for obstructive sleep apnea (OSA). Traditionally, the determination of the optimal pressure for treatment of sleep-disordered breathing was made by m...
Torbjörn Akerstedt,Kenneth P Wright Jr
Torbjörn Akerstedt
Shift work is highly prevalent in industrialized societies (>20%) but, when it includes night work, it has pronounced negative effects on sleep, subjective and physiological sleepiness, performance, accident risk, as well as on health outco...
Lynda Bélanger,Geneviève Belleville,Charles Morin
Lynda Bélanger
The management of hypnotic discontinuation following regular and prolonged use may be a challenging task for patients and clinicians alike. Current evidence suggests that a stepped-care approach may be a cost-effective approach to assist pa...
Hiren Muzumdar,Raanan Arens
Hiren Muzumdar