Philip M Becker
Philip M Becker
Restless leg syndrome, or Willis-Ekbom disease, is a neurosensorimotor disorder with significant impact that is diagnosed through 5 clinical criteria. Adherence to 5 criteria and a thorough physical examination are often sufficient for diag...
David B Rye
David B Rye
Restless legs syndrome (RLS) is a common sensorimotor trait defined by symptoms that interfere with sleep onset and maintenance in a clinically meaningful way. Nonvolitional myoclonus while awake and asleep is a sign of the disorder and an ...
Federica Provini,Giacomo Chiaro
Federica Provini
Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed ...
Richard P Allen
Richard P Allen
Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually pr...
Restless Leg Syndrome Across the Globe: Epidemiology of the Restless Legs Syndrome/Willis-Ekbom Disease [0.03%]
全球不宁腿综合征的流行病学研究
Brian B Koo
Brian B Koo
There are more than 50 epidemiologic studies measuring the prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) across 5 of the 6 inhabited continents (not Australia), most conducted in North America and Europe. Sufficient st...
John H Herman,Max Hirshkowitz
John H Herman
A J Schwichtenberg,Beth A Malow
A J Schwichtenberg
Melatonin is commonly recommended to treat sleep problems in children with developmental disabilities. However, few studies document the efficacy and safety of melatonin in these populations. This article reviews recent studies of melatonin...
Sleep-Related Breathing Disorder, Cognitive Functioning, and Behavioral-Psychiatric Syndromes in Children [0.03%]
儿童睡眠相关呼吸障碍，认知功能和行为精神综合征
Louise M O&#x;Brien
Louise M O&#x;Brien
Childhood sleep disordered breathing (SDB) is strongly associated with a range of cognitive and behavioral disturbances, including some psychiatric diagnoses. Despite this, the majority of children with symptoms of SDB go unrecognized, even...
Suresh Kotagal
Suresh Kotagal
Rapid eye movement (REM) sleep behavior disorder (RBD) is a type of parasomnia that arises out of REM sleep and is characterized by aggressive or violent motor dream enactment in conjunction with preservation of tonic electromyographic acti...
Kleine-Levin Syndrome [0.03%]
克莱因-莱文综合症
Isabelle Arnulf
Isabelle Arnulf
Kleine-Levin syndrome is a rare recurrent encephalopathy primarily affecting teenagers, characterized by relapsing-remitting episodes of hypersomnia along with cognitive, psychiatric and behavioral disturbances. During episodes, patients su...