Daniele Urso,Valentina Gnoni,Eleonora Rollo et al.
Daniele Urso et al.
Parkinson's disease (PD) is characterized by both motor and nonmotor symptoms, including significant sleep disturbances. The glymphatic system, a brain-wide clearance mechanism active during sleep, may play a key role in PD pathology by imp...
Jakub Radziwon,Jarosław Sławek
Jakub Radziwon
Neurodegeneration in dementia with Lewy bodies affects all crucial networks responsible for sleep control and as a result, the sleep cycle is heavily disturbed. Certain sleep syndromes such as rapid eye movement sleep behavior disorder and ...
Exploring the Relationship between Parkinson's Disease and Restless Legs Syndrome [0.03%]
帕金森病与不安腿综合征的关系探讨
Alejandro López-Jiménez,David Anguizola,Alba Garcia-Aragón et al.
Alejandro López-Jiménez et al.
Restless legs syndrome (RLS) frequently coexists with Parkinson's disease (PD), significantly contributing to sleep disturbances and reduced quality of life. This review examines the prevalence, clinical features, pathophysiology, and treat...
Iulia Murasan,Stefania Diaconu,Anastasia Bougea et al.
Iulia Murasan et al.
Shifting away from the traditional perspective on parkisonism, which focused only on the motor state of the patients, recent research proves the importance of early recognition and treatment of non-motor symptoms. Patients with parkinsonism...
Elie Matar,Claudia Lazcano-Ocampo,C Padmakumar
Elie Matar
Sleep and circadian disturbances are prevalent in Parkinson's disease (PD) and become increasingly complex in older adults, where aging-related changes, comorbidities, and polypharmacy further disrupt sleep. This review explores the pathoph...
Shweta Prasad,Rosabel Chen,Pramod Kumar Pal
Shweta Prasad
Sleep dysfunction is a significant component of the non-motor symptom profile in Parkinson's disease (PD). Patients with early onset PD (EOPD) are a unique challenge and may present with specific patterns of sleep disturbances, which tend t...
Valentina Leta,Mattia Tosi,Rosabel Chen et al.
Valentina Leta et al.
Parkinson's disease is a syndrome with many clinical presentations. It is often dominated by visible motor symptoms; however, specific nonmotor features, such as cognitive dysfunction, sleep dysfunction, pain, apathy, dysautonomia, depressi...
Neuroimaging and Sleep Dysfunction in Parkinson's and Parkinsonisms [0.03%]
帕金森病和其他类似 parkinsonism 疾病的睡眠障碍和神经影像学研究
Zheyu Xu,Nicola Pavese,Rhia Ghosh et al.
Zheyu Xu et al.
The article summarizes neuroimaging studies carried out during the last 2 decades to investigate the mechanisms underlying sleep dysfunction in Parkinson's and other synucleinopathies. Rapid eye movement sleep behavior disorder and excessiv...
Genetic Basis of Sleep Dysfunction in Parkinson's Disease and Parkinsonism [0.03%]
帕金森病和帕金森综合征睡眠障碍的遗传基础
Yi-Min Wan,Zhi-Dong Zhou,Eng-King Tan
Yi-Min Wan
Sleep dysfunction in Parkinson's disease (PD) includes rapid eye movement sleep behavior disorder, restless leg syndrome, and excessive daytime sleepiness. These sleep-related manifestations may serve as prodromal signs of PD, particularly ...
Clinical and Biofluid Biomarkers of Sleep Dysfunction in Parkinson's Disease [0.03%]
帕金森病睡眠障碍的临床和生物流体生物标志物
Ruy Gómez-Ocádiz,Per Svenningsson
Ruy Gómez-Ocádiz
Parkinson's disease is a neurodegenerative disorder with an increasing prevalence worldwide. The development of disease-modifying therapies remains a critical priority; however, early intervention is limited by the paucity of robust biomark...