Glycemic Control in Severe Acute Brain Injury: Systematic Review and Meta-analysis with Trial Sequential Analysis [0.03%]
严重急性脑损伤患者的血糖控制：系统评价和荟萃分析及试验序贯分析
Anne-Sophie Worm Fenger,Markus Harboe Olsen,Helene Ravnholt Jensen et al.
Anne-Sophie Worm Fenger et al.
Background: Hyperglycemia is common in intensive care unit (ICU) patients, including those with acute brain injury. Although many studies associate hyperglycemia with increased mortality, the optimal blood glucose target ...
Dynamic GCS Trajectories and Mortality Risk in ICU Patients with Stroke: A Multicenter, Age-Stratified Study [0.03%]
stratify年龄分层的多中心研究中的卒中重症监护病房(ICU)患者的动态GCS轨迹与死亡风险：一项基于年龄划分的多中心研究
Juan Wang,Wei Dai,Man-Man Xu et al.
Juan Wang et al.
Objective: The purpose of this study was to determine whether dynamic Glasgow Coma Scale (GCS) trajectories are associated with mortality risk and provide incremental prognostic information beyond selected baseline clinic...
Effect on Mortality of Anticoagulant Reversal in Acute Intracranial Hemorrhage: A Systematic Review and Meta-analysis [0.03%]
有关急性颅内出血中抗凝血逆转对死亡率影响的系统评价和meta分析研究
Mattias Tallroth,Linda Östlundh,András Büki et al.
Mattias Tallroth et al.
Background: Reversal treatment is used to counterbalance effects of oral anticoagulation in intracranial hemorrhages. Despite effects on reducing hematoma expansion, the impact on mortality remains uncertain. Our aim was ...
Patient-and Caregiver-Centered Outcomes in Survivors of Severe Stroke with Respiratory Failure at 6 Months: A Substudy of the SETPOINT2 Trial [0.03%]
严重呼吸衰竭卒中患者康复中的患者和照料者结局指标——SETPOINT2试验的亚组研究
Matthew N Jaffa,David B Seder,Susanne Muehlschlegel et al.
Matthew N Jaffa et al.
Background/objective: The multicenter trial SETPOINT2 comparing early versus delayed tracheostomy in severe stroke was conducted in Germany and the USA. A pre-specified aim was to assess 6-month patient- and caregiver-rep...
Risk and Timing of Intracerebral Hemorrhage Expansion Among Patients Treated with Antithrombotic Agents [0.03%]
接受抗血栓药物治疗的颅内出血患者病情加重的风险及时间特点
Jennifer A Frontera,Joanna M Marmo,Bavica Gummadi et al.
Jennifer A Frontera et al.
Background: The risk of intracerebral hemorrhage (ICH) hematoma expansion (HE) is highest in the first hours after onset, and coagulopathy is believed to further increase this risk. However, there is a paucity of data com...
Evaluating Utility-Weighted Modified Rankin Scale as an Outcome for Clinical Trials in Subarachnoid Hemorrhage: A SAHaRA Secondary Analysis [0.03%]
蛛网膜下腔出血临床试验的结局指标：SAHaRA队列的二次分析——以效用加权改良Rankin量表为例
Ofer Sadan,Zhuoran Yu,Tianwen Ma et al.
Ofer Sadan et al.
Introduction: The utility-weighted modified Rankin Scale (UW-mRS) is an emerging alternative to the traditional ordinal mRS as a patient-centered measure of functional outcome in clinical trials. As a quasi-continuous par...
Association Among Melatonin Dysregulation, Sleep Disorders, and Sepsis-Associated Delirium: A Prospective Cohort Study with Mediation Analysis [0.03%]
褪黑素失调、睡眠障碍和脓毒症相关性谵妄之间的关联：一项针对中介作用的前瞻性队列研究
Lina Zhao,Qian Cui,Shuoyan Dong et al.
Lina Zhao et al.
Background: Sepsis-associated delirium (SAD) is a life-threatening complication in the intensive care unit (ICU). Although sleep disturbances are common in sepsis, their relationship with SAD remains poorly understood. We...
Cerebral Energy Crisis in the Subacute Phase of Aneurysmal Subarachnoid Hemorrhage: A 31P-MRS Pilot Study on Cerebral Vasospasm and Delayed Cerebral Ischemia [0.03%]
颅内动脉瘤性蛛网膜下腔出血亚急性期脑能量危机：无创检测血管痉挛和迟发性神经元凋亡的体磷磁共振波谱法初步研究
Stephanie Alice Treichl,Ruth Steiger,Johanna Schönherr et al.
Stephanie Alice Treichl et al.
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is followed by a high‑risk subacute phase in which secondary brain injury is a major determinant of outcome, yet in vivo characterization of cerebral bioenergetics du...
Neurofilament Light Protein: A Marker for Injury Severity, Clinical Course, and Outcome Following Moderate to Severe Traumatic Brain Injury [0.03%]
神经丝轻链蛋白：中重度创伤性脑损伤后损伤严重程度、临床过程和预后的标志物
Spyridoula Tsetsou,Leah E McQuillan,Vishruth P Reddy et al.
Spyridoula Tsetsou et al.
Background: Recent studies demonstrate increased neurofilament light (NfL) levels across all types of traumatic brain injury (TBI). We evaluated inter-relationships between acute temporal NfL profiles with dynamic Intensi...
Impact of Complicated Diabetes Mellitus in Patients Following Severe Traumatic Brain Injury [0.03%]
糖尿病对严重颅脑损伤患者预后的影响分析
Ali Seifi,Chloe Kaijia Chui,Alexander Villahermosa et al.
Ali Seifi et al.
Background: The impact of diabetes mellitus (DM) on severe traumatic brain injury (TBI) outcomes remains poorly defined, with prior studies treating DM as a monolithic diagnosis. We hypothesized that post-TBI mortality is...