Mechanisms of Coronavirus Genome Stability As Potential Targets for Antiviral Drugs [0.03%]
冠状病毒基因组稳定机制作为抗病毒药物潜在靶点的可能性研究
S K Yuyukina,D O Zharkov
S K Yuyukina
The COVID-19 pandemic has made it necessary to create antivirals active against the SARS-CoV-2 coronavirus. One of the widely used strategies to fight off viral infections is the use of modified nucleoside analogues that inhibit viral repli...
V A Makarov,V O Popov
V A Makarov
The results of a comprehensive study are presented on the development and creation of an original small PDSTP molecule, able to prevent the SARS-CoV-2 coronavirus infection from binding to the host cell. The PDSTP molecule was designed to e...
The Omicron Variant of the Sars-Cov-2 Virus As the Dominant Agent of a New Risk of Disease amid the COVID-19 Pandemic [0.03%]
新型冠状病毒肺炎大流行背景下OMICRON变异株成为新的疾病风险主体
G G Onishchenko,T E Sizikova,V N Lebedev et al.
G G Onishchenko et al.
Over the two years that have passed since the WHO announced on March 11, 2020, a pandemic of the new coronavirus disease COVID-19, more than 460 million cases of the disease have been detected in the world, of which more than five million h...
T Y Khabrieva,N N Chernogor
T Y Khabrieva
The COVID-19 pandemic is exerting pressure on law and order, testing the strength of their basic elements and subsystems. It is transforming positive law and system-forming processes in the legal sphere, which ensure the functioning of the ...
G N Rykovanov,S N Lebedev,O V Zatsepin et al.
G N Rykovanov et al.
The COVID-19 pandemic has created a public health emergency in Russia and across the world. The wavelike spread of the new coronavirus infection, caused by newly emerging variants of the coronavirus, has led to a high incidence rate in all ...
Wild Animal Migration As a Potential Threat of Introduction of New Viruses into Russia [0.03%]
野生动物迁徙可能给俄罗斯带来新病毒入侵的威胁
A M Shestopalov,A Yu Alekseev,V V Glupov et al.
A M Shestopalov et al.
The SARS-CoV-2 pandemic has shown how serious the problem of re-emerging zoonotic infections is for our existence. Migrations of animals, which are natural reservoirs of a particular virus, play a colossal role in the spread of pathogens to...
A A Ishmukhametov
A A Ishmukhametov
The experience in organizing the creation of innovative immunobiological drugs and vaccines is discussed-from laboratory developments to industrial technologies and the registration of finished forms of effective and safe drugs that are in ...
Evolution of Approaches to Therapeutic Prevention and Treatment of the New Coronavirus Infection [0.03%]
新冠病毒感染防治论治的演变规律
O M Drapkina,I S Yavelov
O M Drapkina
The means of drug intervention for the prevention and treatment of new coronavirus infection (COVID-19) are discussed. Changes in approaches aimed at the main links of pathogenesis and capable of positively influencing the course and outcom...
Development of Drugs with Direct Antiviral Action Based on Azaheterocyclic Systems [0.03%]
基于氮杂杂环体系的直接抗病毒药物开发
V N Charushin,V L Rusinov,M V Varaksin et al.
V N Charushin et al.
This article discusses the results of studies carried out in recent years by a team of scientists from the Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, in cooperation with the First President of Russi...
A V Averyanov,O V Danilevskaya
A V Averyanov
The most common causes of diffuse interstitial lung damage following COVID-19, often either imitate it but have a different nature or remain due to prolonged persistence of SARS-CoV-2 in the lower respiratory tract. A diagnostic algorithm i...