María Ruiz Ortega,Mikhail V Pogorelyy,Anastasia A Minervina et al.
María Ruiz Ortega et al.
T cells recognize a wide range of pathogens using surface receptors that interact directly with peptides presented on major histocompatibility complexes (MHC) encoded by the HLA loci in humans. Understanding the association between T cell r...
Role and modulation of various spinal pathways for human upper limb control in different gravity conditions [0.03%]
不同重力条件下人类上肢控制的脊髓通路的作用及调控机制研究进展
Alice Bruel,Lina Bacha,Emma Boehly et al.
Alice Bruel et al.
Humans can perform movements in various physical environments and positions (corresponding to different experienced gravity), requiring the interaction of the musculoskeletal system, the neural system and the external environment. The neura...
Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity [0.03%]
前生命自动催化RNA网络的生物数学酶动力学模型：降解特定寄生虫的超寄生物催化剂赋予宿主抗寄生虫的能力并宣告了分子免疫的诞生
Magnus Pirovino,Christian Iseli,Joseph A Curran et al.
Magnus Pirovino et al.
Catalysis and specifically autocatalysis are the quintessential building blocks of life. Yet, although autocatalytic networks are necessary, they are not sufficient for the emergence of life-like properties, such as replication and adaptati...
Integrative analysis of ATAC-seq and RNA-seq for cells infected by human T-cell leukemia virus type 1 [0.03%]
人T细胞白血病病毒I型感染的ATAC-seq和RNA-seq数据的综合分析
Azusa Tanaka,Yasuhiro Ishitsuka,Hiroki Ohta et al.
Azusa Tanaka et al.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy (HAM) after a long latent period in a fraction of infected individuals. These HTLV-1-infected cells typically have phenotypes si...
Sparse high-dimensional decomposition of non-primary auditory cortical receptive fields [0.03%]
稀疏分解在非初级听觉皮层感受野中的应用
Shoutik Mukherjee,Behtash Babadi,Shihab Shamma
Shoutik Mukherjee
Characterizing neuronal responses to natural stimuli remains a central goal in sensory neuroscience. In auditory cortical neurons, the stimulus selectivity of elicited spiking activity is summarized by a spectrotemporal receptive field (STR...
The Burr distribution as a model for the delay between key events in an individual's infection history [0.03%]
Burr分布在个体感染历史中关键事件之间延迟的建模中的应用
Nyall Jamieson,Christiana Charalambous,David M Schultz et al.
Nyall Jamieson et al.
Understanding the temporal relationship between key events in an individual's infection history is crucial for disease control. Delay data between events, such as infection and symptom onset times, is doubly censored because the exact time ...
Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity [0.03%]
从抑郁严重程度的模拟EEG预测α5-GABA受体调节的治疗剂量
Alexandre Guet-McCreight,Frank Mazza,Thomas D Prevot et al.
Alexandre Guet-McCreight et al.
Treatment for major depressive disorder (depression) often has partial efficacy and a large portion of patients are treatment resistant. Recent studies implicate reduced somatostatin (SST) interneuron inhibition in depression, and new pharm...
Computational Analysis of MDR1 Variants Predicts Effect on Cancer Cells via their Effect on mRNA Folding [0.03%]
计算分析MDR1基因变异预测其通过影响mRNA折叠对癌细胞的作用
Tal Gutman,Tamir Tuller
Tal Gutman
The P-glycoprotein efflux pump, encoded by the MDR1 gene, is an ATP-driven transporter capable of expelling a diverse array of compounds from cells. Overexpression of this protein is implicated in the multi-drug resistant phenotype observed...
Cancer molecular subtyping using limited multi-omics data with missingness [0.03%]
基于缺失的多组学数据进行癌症分子亚型分类
Yongqi Bu,Jiaxuan Liang,Zhen Li et al.
Yongqi Bu et al.
Diagnosing cancer subtypes is a prerequisite for precise treatment. Existing multi-omics data fusion-based diagnostic solutions build on the requisite of sufficient samples with complete multi-omics data, which is challenging to obtain in c...
Nikoleta E Glynatsi,Vincent Knight,Marc Harper
Nikoleta E Glynatsi
Researchers have explored the performance of Iterated Prisoner's Dilemma strategies for decades, from the celebrated performance of Tit for Tat to the introduction of the zero-determinant strategies and the use of sophisticated learning str...