Data-driven model discovery and model selection for noisy biological systems [0.03%]
数据驱动的生物系统数据模型发现及选择方法研究
Xiaojun Wu,MeiLu McDermott,Adam L MacLean
Xiaojun Wu
Biological systems exhibit complex dynamics that differential equations can often adeptly represent. Ordinary differential equation models are widespread; until recently their construction has required extensive prior knowledge of the syste...
Connectome-based biophysical models of pathological protein spreading in neurodegenerative diseases [0.03%]
基于连接组的神经退行性疾病病理蛋白传播生物物理模型
Peng Ren,Xuehua Cui,Xia Liang
Peng Ren
Neurodegenerative diseases are a group of disorders characterized by progressive degeneration or death of neurons. The complexity of clinical symptoms and irreversibility of disease progression significantly affects individual lives, leadin...
BuDDI: Bulk Deconvolution with Domain Invariance to predict cell-type-specific perturbations from bulk [0.03%]
具有领域不变性的 BuDDI：从粗粒度预测特异于细胞类型的扰动
Natalie R Davidson,Fan Zhang,Casey S Greene
Natalie R Davidson
While single-cell experiments provide deep cellular resolution within a single sample, some single-cell experiments are inherently more challenging than bulk experiments due to dissociation difficulties, cost, or limited tissue availability...
Integration of unpaired single cell omics data by deep transfer graph convolutional network [0.03%]
基于深度转移图卷积网络的非配对单细胞组学数据整合方法研究
Yulong Kan,Yunjing Qi,Zhongxiao Zhang et al.
Yulong Kan et al.
The rapid advance of large-scale atlas-level single cell RNA sequences and single-cell chromatin accessibility data provide extraordinary avenues to broad and deep insight into complex biological mechanism. Leveraging the datasets and trans...
Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits [0.03%]
参与痛觉过敏的背角神经亚回路中兴奋性-抑制性平衡失调的机制研究
Alexander G Ginsberg,Scott F Lempka,Bo Duan et al.
Alexander G Ginsberg et al.
Chronic pain is a wide-spread condition that is debilitating and expensive to manage, costing the United States alone around $600 billion in 2010. In a common symptom of chronic pain called allodynia, non-painful stimuli produce painful res...
Luis L Fonseca,Lucas Böttcher,Borna Mehrad et al.
Luis L Fonseca et al.
This paper describes and validates an algorithm to solve optimal control problems for agent-based models (ABMs). For a given ABM and a given optimal control problem, the algorithm derives a surrogate model, typically lower-dimensional, in t...
Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates [0.03%]
评估残基分辨率蛋白质粗粒模型在生物分子凝集物模拟中的表现
Alejandro Feito,Ignacio Sanchez-Burgos,Ignacio Tejero et al.
Alejandro Feito et al.
Intracellular liquid-liquid phase separation (LLPS) of proteins and nucleic acids is a fundamental mechanism by which cells compartmentalize their components and perform essential biological functions. Molecular simulations play a crucial r...
HighDimMixedModels.jl: Robust high-dimensional mixed-effects models across omics data [0.03%]
高维混合模型软件包HighDimMixedModels.jl及其在组学数据中的应用
Evan Gorstein,Rosa Aghdam,Claudia Solís-Lemus
Evan Gorstein
High-dimensional mixed-effects models are an increasingly important form of regression in which the number of covariates rivals or exceeds the number of samples, which are collected in groups or clusters. The penalized likelihood approach t...
Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach [0.03%]
基于全脑模型的方法探讨星形胶质细胞和神经元网络之间的对话机制
Obaï Bin Ka&#x;b Ali,Alexandre Vidal,Christophe Grova et al.
Obaï Bin Ka&#x;b Ali et al.
Astrocytes critically shape whole-brain structure and function by forming extensive gap junctional networks that intimately and actively interact with neurons. Despite their importance, existing computational models of whole-brain activity ...
Towards constructing a generalized structural 3D breathing human lung model based on experimental volumes, pressures, and strains [0.03%]
基于实验体积、压力和应变构建通用结构化三维呼吸人体肺模型的方法研究
Arif Badrou,Crystal A Mariano,Gustavo O Ramirez et al.
Arif Badrou et al.
Respiratory diseases represent a significant healthcare burden, as evidenced by the devastating impact of COVID-19. Biophysical models offer the possibility to anticipate system behavior and provide insights into physiological functions, ad...