Timothée Poisot,Daniel J Becker,Cole B Brookson et al.
Timothée Poisot et al.
Bayesian identification of differentially expressed isoforms using a novel joint model of RNA-seq data [0.03%]
基于RNA测序数据的新型联合模型的备择转录本的贝叶斯识别方法
Xu Shi,Xiao Wang,Lu Jin et al.
Xu Shi et al.
We develop a Bayesian approach, BayesIso, to identify differentially expressed isoforms from RNA-seq data. The approach features a novel joint model of the sample variability and the deferential state of isoforms. Specifically, the within-s...
ASGCL: Adaptive Sparse Mapping-based graph contrastive learning network for cancer drug response prediction [0.03%]
自适应稀疏映射图对比学习网络在癌症药物反应预测中的应用
Yunyun Dong,Yuanrong Zhang,Yuhua Qian et al.
Yunyun Dong et al.
Personalized cancer drug treatment is emerging as a frontier issue in modern medical research. Considering the genomic differences among cancer patients, determining the most effective drug treatment plan is a complex and crucial task. In r...
Spherical harmonics texture extraction for versatile analysis of biological objects [0.03%]
用于分析生物样本的球谐纹理提取方法研究
Oane Gros,Josiah B Passmore,Noa O Borst et al.
Oane Gros et al.
The characterization of phenotypes in cells or organisms from microscopy data largely depends on differences in the spatial distribution of image intensity. Multiple methods exist for quantifying the intensity distribution - or image textur...
The calcitron: A simple neuron model that implements many learning rules via the calcium control hypothesis [0.03%]
基于钙控制假说的计算神经元模型
Toviah Moldwin,Li Shay Azran,Idan Segev
Toviah Moldwin
Theoretical neuroscientists and machine learning researchers have proposed a variety of learning rules to enable artificial neural networks to effectively perform both supervised and unsupervised learning tasks. It is not always clear, howe...
Giovanni di Sarra,Siddharth Jha,Yasser Roudi
Giovanni di Sarra
Persistent homology applied to the activity of grid cells in the Medial Entorhinal Cortex suggests that this activity lies on a toroidal manifold. By analyzing real data and a simple model, we show that neural oscillations play a key role i...
Correction: Epidemiological and health economic implications of symptom propagation in respiratory pathogens: A mathematical modelling investigation [0.03%]
订正：呼吸道病原体传播的流行病学和卫生经济学含义：数学建模调查
Phoebe Asplin,Matt J Keeling,Rebecca Mancy et al.
Phoebe Asplin et al.
[This corrects the article DOI: 10.1371/journal.pcbi.1012096.]. Copyright: © 2025 Asplin et al. This is an open access article distributed under the ter...
Published Erratum
PLoS computational biology. 2025 Jan 29;21(1):e1012791. DOI:10.1371/journal.pcbi.1012791 2025
DNA spontaneously wrapping around a histone core prefers negative supercoiling: A Brownian dynamics study [0.03%]
缠绕在组蛋白核心上的DNA更倾向于负超螺旋：布朗动力学研究
Chunhong Long,Hongqiong Liang,Biao Wan
Chunhong Long
In eukaryotes, DNA achieves a highly compact structure primarily due to its winding around the histone cores. The nature wrapping of DNA around histone core form a 1.7 left-handed superhelical turns, contributing to negative supercoiling in...
Ten simple rules to complete successfully a computational MSc thesis project [0.03%]
成功完成计算科学硕士论文项目的十条简单建议
Edoardo Saccenti,Cristina Furlan
Edoardo Saccenti
The thesis project is an essential step to obtain an MSc degree. Within STEM and Life Sciences disciplines, computational theses have specific characteristics that differentiate them from wet laboratory ones. In this article, we present Ten...
Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells [0.03%]
C． elegans体壁肌肉细胞生物物理模型和实验分析
Xuexing Du,Jennifer Crodelle,Victor James Barranca et al.
Xuexing Du et al.
This study combines experimental techniques and mathematical modeling to investigate the dynamics of C. elegans body-wall muscle cells. Specifically, by conducting voltage clamp and mutant experiments, we identify key ion channels, particul...