Nowcasting reported covid-19 hospitalizations using de-identified, aggregated medical insurance claims data [0.03%]
使用脱敏的聚合医疗理赔数据对COVID-19报告住院人数进行实时预测
Xueda Shen,Aaron Rumack,Bryan Wilder et al.
Xueda Shen et al.
We propose, implement, and evaluate a method for nowcasting the daily number of new COVID-19 hospitalizations, at the level of individual US states, based on de-identified, aggregated medical insurance claims data. Our analysis proceeds und...
Estimating Mycobacterium tuberculosis transmission in a South African clinic: Spatiotemporal model based on person movements [0.03%]
南非一家诊所中结核分枝杆菌传播的估计：基于人员移动的时空模型
Nicolas Banholzer,Keren Middelkoop,Juane Leukes et al.
Nicolas Banholzer et al.
The risk of Mycobacterium tuberculosis (Mtb) transmission can be high in crowded clinics. We developed a spatiotemporal model of airborne Mtb transmission based on the Wells-Riley equation. We collected environmental, clinical and person-tr...
ChromaFactor: Deconvolution of single-molecule chromatin organization with non-negative matrix factorization [0.03%]
染色质因子：用非负矩阵分解分析单分子染色质组织结构
Laura M Gunsalus,Michael J Keiser,Katherine S Pollard
Laura M Gunsalus
The investigation of chromatin organization in single cells holds great promise for identifying causal relationships between genome structure and function. However, analysis of single-molecule data is hampered by extreme yet inherent hetero...
Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment [0.03%]
肿瘤免疫分隔及聚类算法：识别肿瘤微环境中肿瘤-免疫细胞空间互作标志物
Mai Chan Lau,Jennifer Borowsky,Juha P Väyrynen et al.
Mai Chan Lau et al.
Background: Growing evidence supports the importance of characterizing the organizational patterns of various cellular constituents in the tumor microenvironment in precision oncology. Most existing data on immune cell in...
NAVIP: Unraveling the influence of neighboring small sequence variants on functional impact prediction [0.03%]
NAVIP：解析邻近的小序列变异对功能影响预测的作用
Jan-Simon Baasner,Andreas Rempel,Dakota Howard et al.
Jan-Simon Baasner et al.
Once a suitable reference sequence has been generated, intra-species variation is often assessed by re-sequencing. Variant calling processes can reveal all differences between strains, accessions, genotypes, or individuals. These variants c...
Using a multi-strain infectious disease model with physical information neural networks to study the time dependence of SARS-CoV-2 variants of concern [0.03%]
使用包含物理信息神经网络的多菌株传染病模型来研究值得关注的SARS-CoV-2变异株的时间依赖性
Wenxuan Li,Xu Chen,Suli Liu et al.
Wenxuan Li et al.
With the ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its increasing adaptation to humans, several variants of concern (VOCs) and variants of interest (VOIs) have been identified since late 2020. The...
Integrating multiscale mathematical modeling and multidimensional data reveals the effects of epigenetic instability on acquired drug resistance in cancer [0.03%]
多尺度数学建模和多维数据的整合揭示了表观遗传不稳定对癌症获得性药物抗性的影响
Shun Wang,Jinzhi Lei,Xiufen Zou et al.
Shun Wang et al.
Biological and dynamic mechanisms by which Drug-tolerant persister (DTP) cells contribute to the development of acquired drug resistance have not been fully elucidated. Here, by integrating multidimensional data from drug-treated PC9 cells,...
Matthias C Rillig
Matthias C Rillig
Research lab groups are hotspots for the education of the next generation of scientists, and making these units work as creatively as possible is essential for solving pressing issues in biology, the environment, and beyond. This article hi...
An in silico framework for the rational design of vaginal probiotic therapy [0.03%]
阴道益生菌疗法的理性设计的计算机模拟框架
Christina Y Lee,Sina Bonakdar,Kelly B Arnold
Christina Y Lee
Bacterial vaginosis (BV) is a common condition characterized by a shift in vaginal microbiome composition that is linked to negative reproductive outcomes and increased susceptibility to sexually transmitted infections. Despite the commonal...
Hexagons all the way down: grid cells as a conformal isometric map of space [0.03%]
无限六边形：网格细胞作为空间的保角等距映射
Vemund Sigmundson Schøyen,Kosio Beshkov,Markus Borud Pettersen et al.
Vemund Sigmundson Schøyen et al.
Grid cells in the entorhinal cortex are known for their hexagonal spatial activity patterns and are thought to provide a neural metric for space, and support path integration. In this study, we further investigate grid cells as a metric of ...