Higher-level spatial prediction in natural vision across mouse visual cortex [0.03%]
小鼠视觉皮层中的自然视觉的高级空间预测能力
Micha Heilbron,Floris P de Lange
Micha Heilbron
Theories of predictive processing propose that sensory systems constantly predict incoming signals, based on spatial and temporal context. However, evidence for prediction in sensory cortex largely comes from artificial experiments using si...
Anatomically aware simulation of patient-specific glioblastoma xenografts [0.03%]
基于患者特异性的胶质母细胞瘤解剖学模拟体内移植模型
Adam A Malik,Cecilia Krona,Soumi Kundu et al.
Adam A Malik et al.
Patient-derived cells (PDC) mouse xenografts are increasingly important tools in glioblastoma (GBM) research, essential to investigate case-specific growth patterns and treatment responses. Despite the central role of xenograft models in th...
Therapeutic targeting of oligodendrocytes in an agent-based model of multiple sclerosis [0.03%]
基于多重硬化症代理模型的少突胶质细胞治疗靶向性研究
Georgia R Weatherley,Robyn P Araujo,Samantha J Dando et al.
Georgia R Weatherley et al.
Multiple sclerosis (MS) is a neurodegenerative disease in which misdirected, persistent activity of the immune system degrades the protective myelin sheaths of nerve axons. Historically, treatment of MS has relied on disease-modifying thera...
MMP release following cartilage injury leads to collagen loss in intact tissue: A computational study [0.03%]
软骨损伤后基质金属蛋白酶释放导致完整组织collagen丢失的计算研究
Moustafa Hamada,Atte S A Eskelinen,Joonas P Kosonen et al.
Moustafa Hamada et al.
Collagen damage in articular cartilage plays a key role in post-traumatic osteoarthritis, but the underlying mechanobiological pathways leading to collagen fibril degeneration after injury remain incompletely understood. We hypothesized tha...
A wavelet-based approach generates quantitative, scale-free and hierarchical descriptions of 3D genome structures and new biological insights [0.03%]
基于小波的新型计算方法破解染色体三维结构之谜
Ryan Pellow,Josep M Comeron
Ryan Pellow
Eukaryotes' genomes are organized within nuclei in three-dimensional space, forming structures such as loops, topologically associating domains (TADs), and chromosome territories. This 3D architecture impacts gene regulation and development...
Correction: Simulation insights on the compound action potential in multifascicular nerves [0.03%]
关于多神经纤维复合动作电位的模拟研究（刊误）
PLOS Computational Biology Staff
PLOS Computational Biology Staff
[This corrects the article DOI: 10.1371/journal.pcbi.1013452.]. Copyright: © 2026 The PLOS Computational Biology Staff. This is an open access article d...
Published Erratum
PLoS computational biology. 2026 Jan 20;22(1):e1013902. DOI:10.1371/journal.pcbi.1013902 2026
Gaspar Cano,Richard Kempter
Gaspar Cano
From cortical synfire chains to hippocampal replay, the idea that neural populations can be activated sequentially with precise spike timing is thought to be essential for several brain functions. It has been shown that neuronal sequences w...
Janis Shin,James M Carothers,Herbert M Sauro
Janis Shin
Bayesian Metabolic Control Analysis (BMCA) is a promising framework for inferring metabolic control coefficients in data-limited scenarios, combining Bayesian inference with linear-logarithmic (lin-log) rate laws. These metabolic control co...
TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes [0.03%]
TCR2HLA：从T细胞受体文库中进行校准的HLA基因型推断可以识别具有免疫学相关性的元克隆型
Koshlan Mayer-Blackwell,Anastasia Minervina,Mikhail Pogorelyy et al.
Koshlan Mayer-Blackwell et al.
T cell receptors (TCRs) recognize peptides presented by polymorphic human leukocyte antigen (HLA) molecules, but HLA genotype data are often missing from TCR repertoire sequencing studies. To address this, we developed TCR2HLA, an open-sour...
Structural analysis of antigenic variation and adaptive evolution of the H5N1 neuraminidase gene [0.03%]
H5N1神经氨酸酶基因的抗原变异与适应性进化结构分析
Muyiwa S Adegbaju,Oluwabuyikunmi Owo-Odusi,Eden T Wirtz et al.
Muyiwa S Adegbaju et al.
The concern regarding H5N1 outbreak, particularly the accelerated mutagenesis of its core genomic elements, underscores the persistent threat of influenza to global health. Neuraminidase (NA), a pivotal sialidase integral to virion egress a...