AugGCL: Multimodal graph learning for spatial transcriptomics analysis with enhanced gene and morphological data [0.03%]
基于增强基因和形态学数据的时空转录组学分析多模态图学习方法
Tengfei Ji,Bo Yang,Meng Wang et al.
Tengfei Ji et al.
Spatial transcriptomics enables the measurement of gene expression in intact tissues. Despite this, reconstructing anatomically accurate spatial domains remains challenging, primarily due to expression sparsity, complex tissue architecture ...
How do tumor-associated neutrophils regulate the microenvironmental landscape of brain tumors: Delivery of nano-particles through BBB [0.03%]
肿瘤相关中性粒细胞如何调节脑肿瘤的微环境景观：通过血脑屏障输送纳米颗粒
Haneol Cho,Junho Lee,Sean Lawler et al.
Haneol Cho et al.
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with the very poor survival and high recurrence rate. Tumor-associated neutrophils (TANs) play a pivotal role in regulation of the tumor microenvironment. In this stu...
Bayesian data driven modelling of kinetochore dynamics: Space-time organisation of the human metaphase plate [0.03%]
基于贝叶斯数据驱动的动粒动力学模型：人类中期板的空间时间组织
Constandina Koki,Alessio V Inchingolo,Abdullahi Daniyan et al.
Constandina Koki et al.
Mitosis is a complex self-organising process that achieves high fidelity separation of duplicated chromosomes into two daughter cells through capture and alignment of chromosomes to the spindle mid-plane. Chromosome movements are driven by ...
Homeostasis after injury: How intertwined inference and control underpin post-injury pain and behaviour [0.03%]
损伤后的稳态：如何错综复杂的推断和控制作用支撑了损伤后的疼痛和行为反应
Pranav Mahajan,Peter Dayan,Ben Seymour
Pranav Mahajan
Injuries are an unfortunate but inevitable fact of life, leading to an evolutionary mandate for powerful homeostatic processes of recovery and recuperation. The physiological responses of the body and the immune system must be coordinated w...
A predicted structural interactome reveals binding interference from intrinsically disordered regions [0.03%]
预测的结构相互作用组揭示了内在无序区域的结合干扰
Junhui Peng,Li Zhao
Junhui Peng
Proteins function through dynamic interactions with other proteins in cells, forming complex networks fundamental to cellular processes. While high-resolution and high-throughput methods have significantly advanced our understanding of how ...
Histo-Miner: Deep learning based tissue features extraction pipeline from H&E whole slide images of cutaneous squamous cell carcinoma [0.03%]
基于深度学习的从皮肤鳞状细胞癌H&E全片图像中提取组织特征算法Histominer
Lucas Sancéré,Carina Lorenz,Doris Helbig et al.
Lucas Sancéré et al.
Recent advances in digital pathology have enabled comprehensive analyses of Whole-Slide Images (WSIs) from tissue samples, leveraging high-resolution microscopy and computational capabilities. Despite this progress, available tools for auto...
Learning collective multicellular dynamics with an interacting mean field neural SDE model [0.03%]
基于相互作用平均场神经SDE模型的学习集体多细胞动力学
Qi Jiang,Longquan Li,Lei Zhang et al.
Qi Jiang et al.
The advent of temporal single-cell RNA sequencing (scRNA-seq) data has enabled in-depth investigation of dynamic processes in heterogeneous multicellular systems. Despite remarkable advancements in computational methods for modeling cellula...
Measuring real-time disease transmissibility with temperature-dependent generation intervals [0.03%]
基于温度依赖生成间隔的实时测度疾病传染性
Esther Li Wen Choo,Kris V Parag,Jo Yi Chow et al.
Esther Li Wen Choo et al.
Accurate real-time estimation of the effective reproduction number (Rt) is critical for infectious disease surveillance and response. In vector-borne diseases like dengue, temperature strongly influences disease transmission by affecting ge...
Linking spatial drug heterogeneity to microbial growth dynamics in theory and experiment [0.03%]
理论和实验将空间药物异质性与微生物生长动力学联系起来
Zhijian Hu,Yuzhen Wu,Tomas Freire et al.
Zhijian Hu et al.
Drugs play a central role in limiting bacterial population spread, yet laboratory studies typically assume well-mixed environments when assessing microbial drug responses. In contrast, bacteria in the human body often occupy spatially struc...
Compaction of chromatin domains regulates target search times of proteins [0.03%]
染色质区域的凝聚调节蛋白质靶点搜索时间
Shuvadip Dutta,Adarshkrishnan Rajakumar,Ranjith Padinhateeri et al.
Shuvadip Dutta et al.
Protein molecules must efficiently locate specific DNA sequences within the densely packed chromatin of the cell nucleus. We investigate how the spatial organisation of chromatin, specifically into Topologically Associating Domains (TADs), ...