Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation [0.03%]
分支细胞在复杂环境中的化学趋向性建模为免疫细胞导航提供了见解
Jiayi Liu,Jonathan E Ron,Giulia Rinaldi et al.
Jiayi Liu et al.
Cell migration in vivo is often guided by chemical signaling, i.e., chemotaxis. For immune cells performing chemotaxis in the organism, this process is influenced by the complex geometry of the tissue environment. In this study, we use a th...
Loïc Marrec,Sonja Lehtinen
Loïc Marrec
Identifying the drivers of diversity remains a central challenge in microbial ecology. In microbiota, within-community diversity is often linked to host health, which makes it all the more important to understand. Since many communities ass...
Information uncertainty influences learning strategy from sequentially delayed rewards [0.03%]
信息不确定性影响自延迟回报学习策略的影响
Sean R Maulhardt,Alec Solway,Caroline J Charpentier
Sean R Maulhardt
When receiving a reward after a sequence of multiple events, how do we determine which event caused the reward? This problem, known as temporal credit assignment, can be difficult for humans to solve given the temporal uncertainty in the en...
Multiscale segmentation using hierarchical phase-contrast tomography and deep learning [0.03%]
基于分层相位衬度断层扫描和深度学习的多尺度分割技术
Yang Zhou,Shahab Aslani,Yousef Javanmardi et al.
Yang Zhou et al.
Biomedical systems span multiple spatial scales, encompassing tiny functional units to entire organs. Interpreting these systems through image segmentation requires the effective propagation and integration of information across different s...
A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex [0.03%]
基于Gabor小波的二维基线模型优于皮质视觉区域的三维表面模型
Anna Shafer-Skelton,Timothy F Brady,John T Serences
Anna Shafer-Skelton
Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information...
Emily Liu,Jiaqi Zhang,Caroline Uhler
Emily Liu
Advances in sequencing technologies have enhanced the understanding of gene regulation in cells. In particular, Perturb-seq has enabled high-resolution profiling of the transcriptomic response to genetic perturbations at the single-cell lev...
TEvarSim: A genome simulator for transposable element (TE) variants [0.03%]
TEvarSim：一种用于转座元件变异的基因组模拟器
Jian Miao,Dawei Li
Jian Miao
Transposable element (TE) variants, the presence or absence of TE sequences such as LINE-1, Alu, SVA, and endogenous retroviruses, are a major source of genomic diversity and play critical roles in human health, evolution, and disease. As i...
Capturing individual variation in children's electroencephalograms during nREM sleep [0.03%]
儿童静息状态EEG的个体差异刻画
Verna Heikkinen,Susanne Merz,Riitta Salmelin et al.
Verna Heikkinen et al.
Human brain dynamics are highly unique between individuals: functional neuroimaging studies have recently described functional features that can be used as neural fingerprints. However, the stability of these fingerprints is affected by agi...
SpaConTDS: A multimodal contrastive learning framework for identifying spatial domains by applying tuple disturbing strategy [0.03%]
一种基于元组扰动策略的多模态对比学习框架以识别空间域
Ruiwen Xu,Xiaoqing Cheng,Waiki Ching et al.
Ruiwen Xu et al.
The rational utilization of multimodal spatial transcriptomics (ST) data enables accurate identification of spatial domains, which is essential for investigating cellular structure and functions. In this study, we proposed SpaConTDS, a nove...
Spatial variation in socio-economic vulnerability to Influenza-like Infection for the US population [0.03%]
美国人口感染流感样感染的经济社会脆弱性的地域差异
Shrabani S Tripathy,Joseph V Puthussery,Taveen S Kapoor et al.
Shrabani S Tripathy et al.
This study aims to quantify environmental health impacts and assess risk by understanding the disproportionate burden of infectious diseases, specifically Influenza-like Illness (ILI), across regions with varying socio-economic characterist...