Plastic Arbor: A modern simulation framework for synaptic plasticity-From single synapses to networks of morphological neurons [0.03%]
基于形态的神经元网络突触可塑性的现代模拟框架 Plastic Arbor 及其应用
Jannik Luboeinski,Sebastian Schmitt,Shirin Shafiee et al.
Jannik Luboeinski et al.
Arbor is a software library designed for efficient simulation of large-scale networks of biological neurons with detailed morphological structures. It combines customizable neuronal and synaptic mechanisms with high-performance computing, s...
In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression [0.03%]
基底节丘脑模型模拟捕捉帕金森病病理β频段功率抑制的有效参数范围
Mahboubeh Ahmadipour,Federico Fattorini,Nicolò Meneghetti et al.
Mahboubeh Ahmadipour et al.
In Parkinson's disease (PD), the beta band (12-30 Hz) component of basal ganglia activity is pathologically high. Deep brain stimulation (DBS) is an effective treatment to suppress symptoms of PD and is known to suppress pathological beta a...
A comparative study of statistical methods for identifying differentially expressed genes in spatial transcriptomics [0.03%]
空间转录组学中识别差异表达基因的统计方法比较研究
Yishan Wang,Chenxuan Zang,Ziyi Li et al.
Yishan Wang et al.
Spatial transcriptomics (ST) provides unprecedented insights into gene expression patterns while retaining spatial context, making it a valuable tool for understanding complex tissue architectures, such as those found in cancers. Seurat, by...
Invariant visual object and face learning in the ventral cortical visual pathway: A biologically plausible model [0.03%]
腹侧视觉通路中的视觉物体和面部学习：一个生物合理性模型
Chenfei Zhang,Edmund T Rolls,Jianfeng Feng
Chenfei Zhang
How transform-invariant visual representations of objects and faces are learned in the ventral visual cortical pathway is a massive computational problem. Here we describe key advances towards a biologically plausible four-layer network tha...
Eric S Tvedte,Cecilia Arighi,Matthew B Carson et al.
Eric S Tvedte et al.
A framework for evaluating predicted sperm trajectories in crowded microscopy videos [0.03%]
评估拥挤显微视频中预测精子轨迹的框架
David Hart,Kylie Cashwell,Anita Bhandari et al.
David Hart et al.
Since the 1980s, semi-automated sperm motility analysis of phase contrast microscopy videos has been used to measure and categorize sperm motility patterns. Motility categories are determined from various kinematic parameters such as Curvil...
A pre-trained language model-based cross-modal fusion framework for predicting miRNA-drug resistance and sensitivity associations [0.03%]
基于预训练语言模型的跨模态融合框架用于预测miRNA-药物耐药性和敏感性关系
Nan Sheng,Yunzhi Liu,Ling Gao et al.
Nan Sheng et al.
MicroRNAs (miRNAs) are pivotal regulators of drug resistance and sensitivity in cancer cells, functioning as tumor suppressors or oncogenes that modulate the cellular response to anticancer drugs. While experimental identification of miRNA-...
SpaLSTF: Diffusion-based generative model with BiLSTM and XCA-Transformer for spatial transcriptomics imputation [0.03%]
基于扩散模型的Spatial转录组数据插补方法SpaLSTF：结合BiLSTM和XCA变换器
Lin Yuan,Yufeng Jiang,Boyuan Meng et al.
Lin Yuan et al.
Spatial transcriptomics (ST) technologies provide powerful tools for analyzing spatial distribution patterns of gene expression in tissue samples. However, they are limited by sparse gene detection and incomplete expression coverage. Severa...
Correction: WormSNAP: A software for fast, accurate, and unbiased detection of fluorescent puncta in C. elegans [0.03%]
关于WormSNAP的更正：一个用于快速、准确和无偏差检测秀丽隐杆线虫荧光点的软件
Araven Tiroumalechetty,Elisa B Frankel,Peri T Kurshan
Araven Tiroumalechetty
[This corrects the article DOI: 10.1371/journal.pcbi.1013643.]. Copyright: © 2026 Tiroumalechetty et al. This is an open access article distributed unde...
Published Erratum
PLoS computational biology. 2026 Feb 10;22(2):e1013953. DOI:10.1371/journal.pcbi.1013953 2026
Alicia Lou,Mónica Chagoyen,Juan F Poyatos
Alicia Lou
It is widely acknowledged that development shapes phenotypes, yet the extent to which genes with similar expression patterns during development lead to equivalent organismal phenotypes when mutated remains unclear. Here, we propose addressi...