Tracking SARS-CoV-2 genomic variants in wastewater sequencing data with LolliPop [0.03%]
用LolliPop对污水测序数据中的SARS-CoV-2基因组变异进行监测
David Dreifuss,Ivan Topolsky,Pelin Icer Baykal et al.
David Dreifuss et al.
During the COVID-19 pandemic, wastewater-based epidemiology has progressively taken a central role as a pathogen surveillance tool. Tracking viral loads and variant outbreaks in sewage offers advantages over clinical surveillance methods by...
A dynamical anthrax toxin nanopore biosensor for high-fidelity single-peptide classification [0.03%]
一种高保真的单肽分类动态炭疽毒素纳米孔生物传感器
Jennifer M Colby,Bryan A Krantz
Jennifer M Colby
Nanopore sensing holds the potential to revolutionize proteomics, yet current methods often rely on ensemble aggregation, where thousands of events must be statistically aggregated or averaged to identify a protein or peptide signature. Whi...
PAIRNet: Predicting PIWI cleavage specificity via position-aware RNA interaction modeling [0.03%]
基于位置感知的RNA相互作用模型预测PIWI切割特异性
Lin Zeng,Zhenzhen Li,Enzhi Shen et al.
Lin Zeng et al.
PIWI proteins maintain genome integrity by piRNA-guided cleavage of complementary RNA targets. While Cleave-N'-Seq (CNS-seq) has advanced our understanding of PIWI targeting logic through quantitative mapping of cleavage rates and pairing r...
Paraplume: A fast and accurate antibody paratope prediction method provides insights into repertoire-scale binding dynamics [0.03%]
一种快速准确的抗体互补决定区预测方法揭示了规模性的结合动力学规律
Gabriel Athènes,Adam Woolfe,Thierry Mora et al.
Gabriel Athènes et al.
The specific region of an antibody responsible for binding to an antigen, known as the paratope, is essential for immune recognition. Accurate identification of this small yet critical region can accelerate the development of therapeutic an...
Fitting a lattice model with local and global transmission to spread of a plant disease [0.03%]
局部传染和全局传染的格子模型及其在植物病害传播拟合中的应用
Alex Best,Nik Cunniffe
Alex Best
Understanding, predicting and managing the spread of plant pathogens is crucial given the economic, societal and climatic benefits of plants, including crops and trees. Mathematical models have long been used to investigate disease dynamics...
Quantifying the population-level impact of expanded antibiotic treatment for cholera outbreak management [0.03%]
扩大抗生素治疗方案控制霍乱疫情的影响评估
Sharia M Ahmed,Cormac R LaPrete,Iza Ciglenecki et al.
Sharia M Ahmed et al.
Since 2021, there has been a resurgence in the number of cholera cases, countries affected, and the case fatality rate. Because most cholera patients recover without antibiotic treatment, current cholera treatment guidelines only consider t...
PLOS Computational Biology Staff
PLOS Computational Biology Staff
[This corrects the article DOI: 10.1371/journal.pcbi.1013461.]. Copyright: © 2026 The PLOS Computational Biology Staff. This is an open access article d...
Published Erratum
PLoS computational biology. 2026 Feb 18;22(2):e1013979. DOI:10.1371/journal.pcbi.1013979 2026
Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation [0.03%]
基于高斯过程的电机热点高效搜寻及TMS线圈位置与姿态协同优化算法
David Luis Schultheiss,Zsolt Turi,Joschka Boedecker et al.
David Luis Schultheiss et al.
Transcranial magnetic stimulation (TMS) is a widely used non-invasive brain stimulation technique in neuroscience research and clinical applications. TMS-based motor hotspot hunting describes the process of identifying the optimal scalp loc...
MENDELSEEK: An algorithm that predicts mendelian genes and elucidates what makes them special [0.03%]
预测 Mendel 基因的算法及探究其特殊性的原因
Hongyi Zhou,Brice Edelman,Jeffrey Skolnick
Hongyi Zhou
Although individual Mendelian diseases-those caused by a single gene-are rare, their collective disease burden is substantial. Identifying the causal gene for each condition is essential for accurate diagnosis and effective treatment. Yet, ...
Riley J Arseneau,Leah K MacLean,Jeanette E Boudreau et al.
Riley J Arseneau et al.
The increasing accessibility of next-generation sequencing has empowered researchers to investigate somatic mutations in cancer. The complexity of variant analysis pipelines, terminology, and tool selection remains a major barrier, especial...