Ion dynamics underlying the seizure delay effect of low-frequency electrical stimulation [0.03%]
低频电刺激的癫痫延迟效应及其离子机制研究
Guillaume Girier,Isa Dallmer-Zerbe,Jan Chvojka et al.
Guillaume Girier et al.
The biological mechanisms underlying the spontaneous and recurrent transition to seizures in the epileptic brain are still poorly understood. As a result, seizures remain uncontrolled in a substantial proportion of patients. Brain stimulati...
A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline [0.03%]
用于研究动态细胞间相互作用下卵室内EGFR信号分布的计算框架
Nastassia Pouradier Duteil,Nicole T Revaitis,Mathew G Niepielko et al.
Nastassia Pouradier Duteil et al.
Forming organs requires the appropriate distribution of spatiotemporal signals leading to tissue patterning and morphogenesis. Advances in genetic tools contributed to our understanding of cell signaling and their associated genes. Yet, due...
Using artificial neural networks to reveal the human confidence computation [0.03%]
利用人工神经网络揭示人类信心计算过程
Medha Shekhar,Herrick Fung,Krish Saxena et al.
Medha Shekhar et al.
Humans can evaluate the accuracy of their decisions by providing confidence judgements. Traditional cognitive models have tried to capture the mechanisms underlying this process but remain mostly limited to two-choice tasks with simple stim...
A data-driven biology-based network model reproduces C. elegans premotor neural dynamics [0.03%]
基于数据驱动的生物学模型再现了C. elegans前运动神经动力学现象
Megan Morrison,Lai-Sang Young
Megan Morrison
C. elegans locomotion is composed of switches between forward and reversal states punctuated by turns. This locomotory capability is necessary for the nematode to move towards attractive stimuli, escape noxious chemicals, and explore its en...
A novel generative framework for designing pathogen-targeted antimicrobial peptides with programmable physicochemical properties [0.03%]
一种新颖的生成框架，用于设计针对病原体的目标抗菌肽并具有可编程理化性质
Weizhong Zhao,Kaijieyi Hou,Chang Tang et al.
Weizhong Zhao et al.
Antimicrobial peptides (AMPs) are crucial in addressing the global crisis of bacterial resistance. However, there are still significant limitations in existing methods on de novo AMPs design, especially in designing AMPs with desirable phys...
Gaussian process emulation for exploring complex infectious disease models [0.03%]
高斯过程仿真在复杂传染病模型探索中的应用
Anna M Langmüller,Kiran A Chandrasekher,Benjamin C Haller et al.
Anna M Langmüller et al.
Epidemiological models that aim for a high degree of biological realism by simulating every individual in a population are unavoidably complex, with many free parameters, which makes systematic explorations of their dynamics computationally...
Ten simple rules for running a virtual program to introduce computational biology at the high school level [0.03%]
中学生介绍计算生物学的虚拟项目运行十要则
Hanako Osuga,Matthew C Chan,Katherine Brower et al.
Hanako Osuga et al.
Ten simple rules on how to set up an Innovation Boot Camp for exploitation of research results [0.03%]
十条有关如何举办创业集训营以促进科研成果转化的建议
Susanne Hollmann,Christiane Hollmann,Lesley Tobin de Fuentes et al.
Susanne Hollmann et al.
In today's research landscape, the dissemination and utilisation of results are not only an obligation but essential components of impactful research. Funding agencies are increasingly emphasising the translation of academic findings into p...
Interplay of structured and random interactions in complex ecosystems dynamics [0.03%]
复杂生态系统动力学中结构化和随机相互作用的相互作用
Juan Giral Martínez,Matthieu Barbier,Silvia De Monte
Juan Giral Martínez
Minimal models for complex ecosystems often assume random interactions, whose statistics suffice to predict dynamical and macroecological patterns. However, ecological networks commonly possess a variety of properties, such as hierarchies o...
John S McAlister,Jesse L Brunner,Danielle J Galvin et al.
John S McAlister et al.
Global trade of material goods involves the potential to create pathways for the spread of infectious pathogens. One trade sector in which this synergy is clearly critical is that of wildlife trade networks. This highly complex system invol...