ShapeSpaceExplorer: Analysis of morphological transitions in migrating cells using similarity-based shape space mapping [0.03%]
基于相似性的形状空间映射在迁移细胞形态转变分析中的应用——ShapeSpaceExplorer系统
Samuel D R Jefferyes,Roswitha Gostner,Laura Cooper et al.
Samuel D R Jefferyes et al.
Here we describe the development of ShapeSpaceExplorer, an interactive software for the extraction, visualisation and analysis of complex 2D shape series. We also demonstrate its application to the analysis of cell morphology changes during...
A modelling assessment of the impact of control measures on highly pathogenic avian influenza transmission in poultry in Great Britain [0.03%]
英国家禽高致病性禽流感传播控制措施的效果评估模型分析
Christopher N Davis,Edward M Hill,Chris P Jewell et al.
Christopher N Davis et al.
Since 2020, large-scale outbreaks of highly pathogenic avian influenza (HPAI) H5N1 in Great Britain have resulted in substantial poultry mortality and economic losses. Alongside the costs, the risk of circulation leading to a viral reassort...
GAN-enhanced machine learning and metabolic modeling identify reprogramming in pancreatic cancer [0.03%]
基于生成对抗网络的机器学习和代谢建模识别出胰腺癌中的重编程现象
Tahereh Razmpour,Masoud Tabibian,Arman Roohi et al.
Tahereh Razmpour et al.
Pancreatic ductal adenocarcinoma is one of the deadliest forms of cancer, presenting significant clinical challenges due to poor prognosis and limited treatment options. Understanding the metabolic reprogramming that drives this disease is ...
DSCA-HLAII: A dual-stream cross-attention model for predicting peptide-HLA class II interaction and presentation [0.03%]
一种预测肽-HLA II类相互作用和呈递的双流交叉注意模型(DSCA-HLAII)
Ke Yan,Hongjun Yu,Shutao Chen et al.
Ke Yan et al.
Motivation: The interaction between peptides and human leukocyte antigen class II (HLA-II) molecules plays a pivotal role in adaptive immune responses, as HLA-II mediates the recognition of exogenous antigens and initiate...
CellPredX, a computational framework for cross-data type, cross-sample, and cross-protocol cell type annotation through domain adaptation and deep metric learning [0.03%]
一种计算框架，可通过领域适应和深度度量学习对跨数据类型、跨样本和跨协议的细胞类型进行注释
Yan Liu,Yu Xia,He Yan et al.
Yan Liu et al.
Accurate cell type annotation is fundamental to single-cell analysis, yet remains challenging across heterogeneous datasets and modalities. In particular, transferring labels between scRNA-seq and scATAC-seq data poses unique difficulties d...
Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution [0.03%]
在杂交种群中叠加共祖先关系可以得到个体层面的亲缘系数度量
Danfeng Chen,John D Storey
Danfeng Chen
The admixture model is widely applied to estimate and interpret population structure among individuals. Here we consider a "standard admixture" model that assumes the admixed populations are unrelated and also a generalized model, where the...
When predict can also explain: Few-shot prediction to select better neural latents [0.03%]
当预测也可以解释：少数样本预测选择更好的神经隐变量
Kabir V Dabholkar,Omri Barak
Kabir V Dabholkar
Latent variable models serve as powerful tools to infer underlying dynamics from observed neural activity. Ideally, the inferred dynamics should align with true ones. However, due to the absence of ground truth data, prediction benchmarks a...
Cell-DINO: Self-supervised image-based embeddings for cell fluorescent microscopy [0.03%]
基于图像的细胞荧光显微镜自监督嵌入式表示学习(Cell-DINO)
Théo Moutakanni,Camille Couprie,Seungeun Yi et al.
Théo Moutakanni et al.
Accurately quantifying cellular morphology at scale could substantially empower existing single-cell approaches. However, measuring cell morphology remains an active field of research, which has inspired multiple computer vision algorithms ...
Modeling tissue-scale ciliary transport and mixing in three-dimensional Newtonian flow [0.03%]
三维牛顿流体中组织尺度纤毛传输与混合的模型研究
Ling Xu,Pejman Senaei,Yi Jiang
Ling Xu
Mucociliary clearance is the primary defense mechanism in our respiratory system against aerosol pathogens and allergens. The rhythmic movement of cilia on airway-lining cells propels mucus flow, driving the movement of trapped particles. H...
Inverse modeling unveils governing law of mechano-chemical dynamics of epithelial migration [0.03%]
基于上皮迁移的逆向建模及其力学化学演化规律
Yuto Kikuchi,Yoshifumi Asakura,Kazuhiro Aoki et al.
Yuto Kikuchi et al.
Collective cell migration is fundamental to tissue homeostasis and underlies biological processes such as wound healing and cancer invasion. Previous work has proposed governing equations to describe how chemical and mechanical inputs regul...