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期刊名:Plos computational biology

缩写:PLOS COMPUT BIOL

ISSN:1553-734X

e-ISSN:1553-7358

IF/分区:3.6/Q1

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共收录本刊相关文章索引11926
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Josephine Solowiej-Wedderburn,Jennifer T Pentz,Ludvig Lizana et al. Josephine Solowiej-Wedderburn et al.
[This corrects the article DOI: 10.1371/journal.pcbi.1013213.]. Copyright: © 2026 Solowiej-Wedderburn et al. This is an open access article distributed ...
Cristian Arsene,Alexander Gates,Anne-Katrin Römmert et al. Cristian Arsene et al.
We present a novel method for analyzing the folding of intrinsically disordered proteins (IDPs), such as Tau and phosphorylated Tau (pTau), in solution. Using cross-linking mass spectrometry (XL-MS) combined with a new downstream analysis f...
Asmita Roy,Xianyang Zhang Asmita Roy
In genome-wide epigenetic studies, determining how exposures (e.g., Single Nucleotide Polymorphisms) affect outcomes (e.g., gene expression) through intermediate variables, such as DNA methylation, is a key challenge. Mediation analysis pro...
Mingming Lin,Kai Li,Xiaofan Wang et al. Mingming Lin et al.
Background: Heart failure with preserved ejection fraction (HFpEF) represents a heterogeneous syndrome with diverse pathophysiological mechanisms and limited therapeutic options. Peak strain dispersion (PSD) has emerged a...
Björn Vessman,Pablo Guridi-Fernández,Flor Inés Arias-Sánchez et al. Björn Vessman et al.
There is increasing interest in artificially selecting or breeding microbial communities, but experiments have reported modest success. Here, we develop computational models to simulate two previously known selection methods and compare the...
Louis González,Andrew Mugler Louis González
Cells frequently employ extracellular vesicles, or exosomes, to signal across long distances and coordinate collective actions. Exosomes diffuse slowly, can be actively degraded, and contain stochastic amounts of molecular cargo. These feat...
Haiyue Wang,Wensheng Zhang,Zaiyi Liu et al. Haiyue Wang et al.
Spatially resolved transcriptomics (SRT) enables the simultaneous capture of gene expression profiles and spatial localization, providing valuable insights into tissue architecture. However, the preservation of spatial information requires ...
Max Ticó,Emerson Sullivan,Roderic Guigó et al. Max Ticó et al.
Genome annotations provide the essential framework for genomic analyses, capturing our current knowledge of gene structure and function as inferred from computational predictions and experimental evidence. Even as automated annotation pipel...
Robert Moss,Saber Dini,Steven Kho et al. Robert Moss et al.
The human spleen significantly influences red blood cell (RBC) dynamics due to its ability to retain and/or remove RBCs from peripheral blood circulation. This filtering can mediate a range of malaria disease manifestations, depending on th...
Vivek Kumar,Yosuke Hasegawa,Prashant Kumar et al. Vivek Kumar et al.
Blood vessel pruning during angiogenesis is the optimization process of the branching pattern to improve the transport properties of a vascular network. Recent studies show that part of endothelial cells (ECs) subjected to lower shear stres...