Pre-disease biomarkers of persistent organic pollutants (POPs) and amyotrophic lateral sclerosis (ALS) risk in Finland [0.03%]
芬兰持久性有机污染物（POPs）的病前生物标志物和肌萎缩侧索硬化症（ALS）风险的研究
Ian W Tang,Paul Knekt,Panu Rantakokko et al.
Ian W Tang et al.
Background: Persistent organic pollutants (POPs) are toxic chemicals that bioaccumulate and were used in pesticides and industrial products/processes. POP-exposed occupations and environmental exposure to POPs have been a...
Dietary exposure to per- and polyfluoroalkyl substances and health risk assessment in 7-year-old children in Shandong, China [0.03%]
山东省7岁儿童饮食暴露于含氟化合物及健康风险评估
Yan Zhang,Qian Yao,Rong Shi et al.
Yan Zhang et al.
Background: Dietary intake, especially foods of animal-origin, is an important source of per- and polyfluoroalkyl substances (PFAS) exposure to the general population. However, the distribution of legacy and emerging PFAS...
Unlocking the Power of Data Harmonization in Environmental Health Sciences: A Comprehensive Exploration of Significance, Use Cases, and Recommendations for Standardization Efforts [0.03%]
环境健康科学中数据和谐化的力量：显著性、用例及标准化建议的全面探讨
Jeanette A Stingone,H C Bledsoe,Grace Cooney et al.
Jeanette A Stingone et al.
Background: The field of environmental health sciences increasingly demands comprehensive and diverse datasets, particularly in response to emerging research areas such as climate change, mixtures, and exposomics. The dat...
Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity [0.03%]
用于预测药物性肝损伤和心毒性的扩展Tox21生物学检测板
Tuan Xu,Masato Ooka,Jinghua Zhao et al.
Tuan Xu et al.
Background: Toxicology in the 21st Century (Tox21) assay data provide a valuable resource for the prediction of in vivo toxicity using machine learning models. However, the performances of these models previously develope...
Trends in serum levels of emerging and legacy per- and polyfluoroalkyl substances from 2008 to 2018: a longitudinal study in China [0.03%]
中国新兴和传统含氟素物质血清水平的纵向变化（2008-2018年）
Xu Cheng,Yu Wang,Jin Zhang et al.
Xu Cheng et al.
Background: China is an important producer and consumer of per- and polyfluoroalkyl substances (PFAS), but there is limited understanding of longitudinal trends of PFAS in Chinese people. ...
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood [0.03%]
孕期吸烟暴露与新生儿血液表观基因组甲基化状况的关系
Thanh T Hoang,Marta Cosin-Tomas,Yunsung Lee et al.
Thanh T Hoang et al.
Background: Maternal sustained smoking during pregnancy is associated with thousands of differentially methylated CpGs in newborns, but impacts of other prenatal tobacco smoking exposures remain unclear. ...
Gregory J Smith,Robert M Immormino,Martin T Ferris et al.
Gregory J Smith et al.
Background: Exposure to the ambient air pollutant ozone (O3) is associated with adverse respiratory health outcomes. Rodent models have been used to identify mechanisms of response to O3 but their utility has been questio...
Exposures to drinking water contaminants in community water systems and risk of ovarian cancer in the California Teachers Study cohort [0.03%]
加利福尼亚教师队列中社区供水系统污染与卵巢癌风险的关系
Maya Spaur,Lauren M Hurwitz,Danielle N Medgyesi et al.
Maya Spaur et al.
Background: Several drinking water contaminants are known or suspected carcinogens; however, there are only a few investigations of drinking water exposures and ovarian cancer. We evaluated associations between regulated ...
The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort [0.03%]
血铅与心血管疾病发病率和死亡率的关联：Strong Heart研究队列的结果
Wil Lieberman-Cribbin,Anne E Nigra,Allison Kupsco et al.
Wil Lieberman-Cribbin et al.
Background: Evidence on lead and the burden of cardiovascular disease (CVD) derived from National Health and Nutrition Examination Survey (NHANES) data, a general sample of the U.S. population, lacks sufficient representa...
Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics [0.03%]
环境相关剂量的双酚A和S在子宫内的暴露跨世代干扰生殖细胞编程（单核多组学解析）
Liang Zhao,Mingxin Shi,Sarayut Winuthayanon et al.
Liang Zhao et al.
Background: Exposure to endocrine-disrupting chemicals (EDCs), such as bisphenol (BP) A, disrupts reproduction across generations. Germ cell epigenetic alterations are proposed to mediate these transgenerational defects. ...