Calcium-Chitosan Scaffolds With Simvastatin Enhance Bone Regeneration in Critical-Sized Calvarial Defects in Rats [0.03%]
载辛伐他汀的胶原-壳聚糖支架促进大鼠颅骨缺损修复中的成骨效应
Ruan Henrique Delmonica Barra,Elisa Mara de Abreu Furquim,Edilson Ervolino et al.
Ruan Henrique Delmonica Barra et al.
Bone regeneration in critical defects remains a clinical challenge, motivating the development of biomaterials capable of supporting osteogenesis and modulating local biological responses. This study investigated the regenerative potential ...
Low Percent Copper Doping Limits Bacterial Adhesion on Fluorapatite-Based Bone Scaffolds [0.03%]
低铜浓度下铜掺杂的羟基磷灰石骨支架抗菌粘附性能的研究
Pooya Elahi,Samantha K Steyl,Alec Griffin et al.
Pooya Elahi et al.
Natural and engineered bone grafts are widely used in orthopedic and dental reconstruction; however, infection remains a persistent clinical challenge. Fluorapatite (FAp) is a chemically stable and osteoconductive bone substitute, but it la...
Safety, Toxicity, and Regulation of Biomaterials: A Systematic Review of Global Frameworks and Emerging Challenges [0.03%]
生物材料的安全性、毒性及监管：全球框架与新兴挑战的系统评价
Abhishek Rawat,Anoushka Khanna,Bhupendra Singh Butola et al.
Abhishek Rawat et al.
Biomaterials are natural or synthetic materials designed to interact with biological systems for medical, environmental, or industrial applications. Despite their expanding market and crucial healthcare role, ensuring safety and establishin...
Early Osseointegration and Long-Term Biocompatibility of Porous Zirconia and Alumina Matrix Composite Scaffolds in Calvarial and Femoral Bone Defects in an Ovine Animal Model [0.03%]
多孔氧化锆和氧化铝基复合支架在绵羊颅骨和股骨缺损模型中的早期骨整合及长期生物相容性研究
Ina Lackner,Ulrike Deisinger,Yvonne Mödinger et al.
Ina Lackner et al.
Bone regeneration scaffolds represent a promising solution for bone grafting of large and severe bone defects. The ideal bone substitute material is considered to have excellent biocompatibility, osteoconductivity, osteoinductivity, and mec...
Complementary Surface Characterization Methods for Qualitative Detection of Oil Residues on Metallic Biomaterials [0.03%]
用于金属生物材料表面油污定性检测的表征方法及其互补性研究
Gopinath Mani,Corey LaSalle,Molly Gjerde et al.
Gopinath Mani et al.
Residual machining oils on metallic medical device components may pose potential biocompatibility risks and often trigger extensive chemical characterization in accordance with ISO 10993-18. For metallic biomaterials, however, such residues...
Local Treatment of Osteomyelitis Using Sodium Calcium Silicophosphate Bioceramics for Antibiotic Delivery: In Vitro Assays and Clinical Evaluation [0.03%]
用于局部治疗的载药生物陶瓷材料结合应用体外评价及临床效果评估研究
Gabriela Mesa-Mejia,Johanny Aguillón-Osma,Johan Villada-Ramos et al.
Gabriela Mesa-Mejia et al.
Osteomyelitis is a serious bone infection that causes inflammation and damage to the affected tissue. Conventional treatments include prolonged, high-dose systemic antibiotic therapy, and debridement surgery, which may ultimately lead to am...
The Influence of the Bone Scaffold Biodegradation Process on Bone Remodeling in Critical Size Bone Defects: A Finite Element Analysis [0.03%]
关于骨支架生物降解过程对临界尺寸骨缺损骨重建的影响的有限元分析
Piotr Prochor,Anita Gryko,Jarosław Filipiak et al.
Piotr Prochor et al.
One of the main features to consider when designing bioresorbable bone scaffolds is the degradation rate of the material. The literature focuses mostly on its influence on mechanical properties, omitting its effect on the bone remodeling pr...
Enhanced Delivery of Antimicrobial Peptide via Dual-Functionalized Silica Nanoparticles Achieves Efficient Staphylococcus aureus Biofilm Eradication [0.03%]
负载双重功能的二氧化硅纳米颗粒递送抗菌肽高效清除金黄色葡萄球菌生物被膜
Ayşenur Pamukçu,M Baran Karakaplan,Nursu Erdoğan et al.
Ayşenur Pamukçu et al.
Antimicrobial peptides (AMPs) present potential alternatives; nevertheless, their effectiveness is frequently impeded by inadequate biofilm penetration and breakdown inside the extracellular polymeric substance (EPS) matrix. This study invo...
Optimized Protocol for the Isolation of UHMWPE Wear Debris by Lyophilization and Chemometric Identification (EDS/PCA) [0.03%]
通过冻干法优化超高分子量聚乙烯磨损颗粒分离及化学计量学分析(EDS/PCA)识别流程
Luis Antonio da Costa Bento,Vanessa Kapps,Rafael Mello Trommer et al.
Luis Antonio da Costa Bento et al.
Aseptic osteolysis induced by ultra-high-molecular-weight polyethylene (UHMWPE) wear debris has historically been a major cause of late failure in total hip arthroplasty, highlighting the need for more robust methods to isolate and identify...
In Vivo Evaluation of Preconditioned Adipose-Derived Stromal Cells Reveals Limited Impact on Vascular and ECM Remodeling in Polymer Scaffolds [0.03%]
预条件脂肪来源基质细胞的活体评估显示聚合物支架中的血管和ECM重塑作用有限
Erika Pinheiro-Machado,Timara Kuiper,Romy H Huurman et al.
Erika Pinheiro-Machado et al.
Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood ve...