Preparation and Characterization of Biopolymeric-Based Orally Dissolving Mucoadhesive Hydrogels Loaded With Rosuvastatin for the Effective Treatment of Aphthous Ulcer [0.03%]
用于治疗复发性口腔溃疡的生物聚合物类 rosuvastatin 口服溶解粘附水凝胶的制备及表征
Ishika Dey,Koushik Ghosh,Ahana Hazra et al.
Ishika Dey et al.
The primary objective of this study was to develop and evaluate a sustained-release mucoadhesive hydrogel loaded with Rosuvastatin (RSV) to enhance the treatment of aphthous ulcers. By leveraging the pleiotropic anti-inflammatory and tissue...
Controversies Surrounding Critical-Size Defects: Influence of Age and Biological Characteristics [0.03%]
关于关键尺寸缺陷的争议：年龄和生物特征的影响
Andrew Nordlund,Hana Shah,Nicholas A Mirsky et al.
Andrew Nordlund et al.
Critical-size defects (CSDs) in craniofacial reconstruction refer to osseous gaps that fail to heal spontaneously, increasing the risk of neurological impairment and craniofacial dysmorphology. Despite decades of investigation, controversy ...
Corrosion-Driven Degradation of Mg WE43 Plates for Mandibular Fracture Fixation: An In-Silico Study [0.03%]
镁WE43板在下颌骨折固定的腐蚀驱动退化：一项计算机模拟研究
Reza Izadi,Mohadese Rajaeirad,Sandipan Roy
Reza Izadi
Biodegradable Mg WE43 alloys offer bone-matched stiffness and osteogenic degradation products for mandibular fracture fixation but undergo unpredictable uniform and pitting corrosion that may compromise early stability. Integrating corrosio...
Resorption Pattern and Bone Regeneration Using a Synthetic Bone Substitute Block With or Without rhBMP-2 and Bisphosphonates: An in Vivo Experiment [0.03%]
一种合成骨替代物块在rhBMP-2和双磷酸盐存在或不存在情况下的骨吸收模式及骨再生：一项体内实验研究
Seung Ha Yoo,Young Woo Song,Seung-Hyun Park et al.
Seung Ha Yoo et al.
This study aimed to investigate whether recombinant human bone morphogenetic protein-2 (rhBMP-2) or bisphosphonate added to synthetic block bone substitute influences new bone formation and grafting material degradation patterns. In a rabbi...
Multifunctional Nanoparticles for Theranostics of Protein Misfolding Diseases: A Systematic Review [0.03%]
蛋白质错误折叠疾病的诊疗纳米颗粒系统评价
Huraira Tariq,Shahrukh Khan,Hadiqa Shahid et al.
Huraira Tariq et al.
Protein misfolding disorders such as Parkinson's disease, Alzheimer's disease, islet amyloidosis, and several other diseases (amyloidosis) are characterized by the pathological accumulation of misfolded proteins that aggregate into toxic ol...
Smart Bioresponsive Hydrogels for Chronic Wound Healing: Design, Therapeutic Functionalization, and Emerging Digital Health Integration [0.03%]
用于慢性伤口愈合的智能生物响应水凝胶：设计、治疗功能化及新兴数字健康集成
Mayuresh Ramesh Redkar,Sonal Yallapa Nalkar,Manojkumar Mukundrao Nitalikar et al.
Mayuresh Ramesh Redkar et al.
Smart bioresponsive hydrogels have emerged as a transformative solution for the management of chronic wounds, such as diabetic foot ulcers, venous leg ulcers, and pressure sores, which are often complicated by persistent inflammation, infec...
EGFR-Targeted RNA-Exosome Nanoparticles Delivering Paclitaxel Suppress Colorectal Cancer via PRELP Upregulation [0.03%]
表皮生长因子受体靶向的RNA-外泌体纳米颗粒通过上调PRELP递送紫杉醇抑制结直肠癌
QingHan Li,Yong Ji,ZuoJun Zhen et al.
QingHan Li et al.
Targeted drug delivery remains a major challenge in the treatment of colorectal cancer (CRC), particularly in overcoming tumor immune evasion. Exosome-based nanocarriers have shown considerable promise due to their tumor-targeting capabilit...
Exploring the Potential of Cerium-Zinc Co-Incorporated Titanium Implants for Enhanced Antibacterial Activity, Cytocompatibility, and Bone Regeneration [0.03%]
掺铈锌钛植入物的抗菌、细胞相容及促骨再生性能研究
Ann Mary Mathew,P V Sreya,Kalimuthu Vignesh et al.
Ann Mary Mathew et al.
The present study aspires to develop multifunctional titanium (Ti) surfaces by the incorporation of both cerium (Ce) and zinc (Zn) ions to ensure the success of orthopedic implants. The dual-element incorporation was facilitated by the alka...
Bone Healing Response of Two Different Silicate-Containing Calcium Phosphate Synthetic Bone Grafts in a Rabbit Femoral Critical-Sized Defect Model [0.03%]
两种含硅酸盐钙磷酸盐合成骨移植材料的骨诱导行为及机制研究——以兔股骨大段缺损模型为例
Iain R Gibson,Jordan C Conway,Viviana R Lopes et al.
Iain R Gibson et al.
Synthetic materials based on calcium phosphates (CaP) are frequently used as bone graft substitutes when natural bone grafts are not available or not suitable. One approach used to enhance their performance is the incorporation of ions such...
Engineering Vascular Grafts: The Intersection of Manufacturing Techniques and Immune Response Modulation [0.03%]
工程血管移植物：制造技术与免疫反应调节的交叉点
Jada K Sandridge,Samantha C Hall,Gary L Bowlin
Jada K Sandridge
Cardiovascular disease is the leading cause of mortality worldwide. The most common treatment option is bypass grafting surgery, and the success of this procedure depends on the availability and performance of the vascular graft. Autologous...