Reorganization of suprachiasmatic nucleus networks under 24-h LDLD conditions [0.03%]
24小时明暗交替周期中视交叉上核神经网络的重塑
Lily Yan,Rae Silver,Michael Gorman
Lily Yan
The suprachiasmatic nucleus (SCN), locus of the master circadian clock in the brain, is comprised of multioscillator neural networks that are highly plastic in responding to environmental lighting conditions. Under a 24-h light:dark:light:d...
Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice [0.03%]
视前核区损伤对Per2::luc小鼠摄食诱导的运动节律和肝脏Per2表达的影响
Yu Tahara,Akiko Hirao,Takahiro Moriya et al.
Yu Tahara et al.
Restricted feeding induces anticipatory activity rhythm and also entrains the peripheral circadian clocks, although the underlying brain mechanisms have not been fully elucidated. The dorsomedial hypothalamus (DMH) has been implicated in th...
Daan R van der Veen,Simon N Archer
Daan R van der Veen
A functional knockout of Period3 in mice (mPer3(-/-)) results in a mildly altered circadian phenotype, and mPer3 shows a redundant role within the circadian clock. In this study, the authors reevaluated the Per3(-/ -) behavioral phenotype o...
A mathematical model of homeostatic regulation of sleep-wake cycles by hypocretin/orexin [0.03%]
下丘脑分泌素/食欲素调节睡眠-觉醒周期的稳态模型
Svetlana Postnova,Karlheinz Voigt,Hans Albert Braun
Svetlana Postnova
We introduce a physiology-based mathematical model of sleep-wake cycles, suggesting a novel mechanism of homeostatic regulation of sleep. In this model, the homeostatic process is determined by the neuropeptide hypocretin/ orexin, which is ...
Photoperiod history differentially impacts reproduction and immune function in adult Siberian hamsters [0.03%]
光周期历史对成年西伯利亚仓鼠繁殖和免疫功能的影响不同
Brian J Prendergast,Leah M Pyter
Brian J Prendergast
Seasonal changes in numerous aspects of mammalian immune function arise as a result of the annual variation in environmental day length (photoperiod), but it is not known if absolute photoperiod or relative change in photoperiod drives thes...
Millisecond light pulses make mice stop running, then display prolonged sleep-like behavior in the absence of light [0.03%]
毫秒级光脉冲使小鼠停止奔跑，并在没有光线的情况下表现出长时间的类似睡眠的行为
L P Morin,K M Studholme
L P Morin
Masking, measured as a decrease in nocturnal rodent wheel running, is a visual system response to rod/cone and retinal ganglion cell photoreception. Here, the authors show that a few milliseconds of light are sufficient to initiate masking,...
Joseph LeSauter,Taslima Bhuiyan,Takao Shimazoe et al.
Joseph LeSauter et al.
Calbindin-D28K (CalB)-containing cells form a distinct cluster within the core of the hamster suprachiasmatic nucleus (SCN). These cells are directly retinorecipient but lack detectable rhythms in clock gene expression or electrical activit...
Correlation with behavioral activity and rest implies circadian regulation by SCN neuronal activity levels [0.03%]
与行为活性和休息的相关性表明视交叉上核神经元活性水平的昼夜调节作用
Thijs Houben,Tom Deboer,Floor van Oosterhout et al.
Thijs Houben et al.
The SCN of the hypothalamus contains a major pacemaker, which exhibits 24-h rhythms in electrical impulse frequency. Although it is known that SCN electrical activity is high during the day and low during the night, the precise relationship...
Diurnal variations in natural and drug reward, mesolimbic tyrosine hydroxylase, and clock gene expression in the male rat [0.03%]
大鼠多巴胺能神经元的昼夜节律及其与自然奖赏和药物奖赏的关系研究
Ian C Webb,Ricardo M Baltazar,Xu Wang et al.
Ian C Webb et al.
The impact of the circadian timing system upon behavior and physiology is pervasive, and previous evidence suggests a circadian modulation of drug-seeking behavior and responsiveness to drugs of abuse. To further characterize daily rhythms ...
Synergic entrainment of Drosophila's circadian clock by light and temperature [0.03%]
光和温度对果蝇生物钟的协同同步作用
Taishi Yoshii,Stefano Vanin,Rodolfo Costa et al.
Taishi Yoshii et al.
Daily light and temperature cycles are considered the most important zeitgebers for circadian clocks in many organisms. The influence of each single zeitgeber on the clock has been well studied, but little is known about any synergistic eff...