The acetyltransferase Clock is dispensable for circadian aftereffects in mice [0.03%]
乙酰转移酶Clock在小鼠生物钟后遗效应中可有可无
Christian Beaulé,Hai-Ying M Cheng
Christian Beaulé
Recent demonstration of the histone acetyltransferase activity of the Clock gene greatly expanded the regulatory role of circadian clocks in gene transcription. Clock and its partner Bmal1 are responsible for the generation of circadian osc...
Daily rhythms in olfactory discrimination depend on clock genes but not the suprachiasmatic nucleus [0.03%]
嗅觉辨别能力的日常节律依赖于生物钟基因而非视交叉上核
Daniel Granados-Fuentes,Gal Ben-Josef,Gavin Perry et al.
Daniel Granados-Fuentes et al.
The suprachiasmatic nucleus (SCN) regulates a wide range of daily behaviors and has been described as the master circadian pacemaker. The role of daily rhythmicity in other tissues, however, is unknown. We hypothesized that circadian change...
Valproic acid phase shifts the rhythmic expression of Period2::Luciferase [0.03%]
valproic酸使Period2::Luciferase的节律表达提前
Anne-Sofie Johansson,Johan Brask,Björn Owe-Larsson et al.
Anne-Sofie Johansson et al.
Valproic acid (VPA) is an anticonvulsant used to treat bipolar disorder, a psychiatric disease associated with disturbances in circadian rhythmicity. Little is known about how VPA affects circadian rhythms. The authors cultured tissues cont...
Genetic interaction of Per1 and Dec1/2 in the regulation of circadian locomotor activity [0.03%]
Per1与Dec1/2在调控昼夜节律运动活动中的遗传相互作用关系研究
Brid Bode,Ali Shahmoradi,Reshma Taneja et al.
Brid Bode et al.
In mammals, 24-h rhythms are controlled by a hierarchical system of endogenous clocks, with a circadian pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus that synchronizes peripheral oscillators throughout the body. ...
Functional conservation of clock output signaling between flies and intertidal crabs [0.03%]
来自果蝇和潮间带寄居蟹时钟输出信号的功能保守性
Esteban J Beckwith,Katherine R Lelito,Yun-Wei A Hsu et al.
Esteban J Beckwith et al.
Intertidal species have both circadian and circatidal clocks. Although the behavioral evidence for these oscillators is more than 5 decades old, virtually nothing is known about their molecular clockwork. Pigment-dispersing hormones (PDHs) ...
Light affects the branching pattern of peptidergic circadian pacemaker neurons in the brain of the cockroach Leucophaea maderae [0.03%]
光影响美洲大蠊脑肽能昼夜节律起搏神经元的分支模式
Hongying Wei,Monika Stengl
Hongying Wei
Pigment-dispersing factor-immunoreactive neurons anterior to the accessory medulla (aPDFMes) in the optic lobes of insects are circadian pacemaker neurons in cockroaches and fruit flies. The authors examined whether any of the aPDFMes of th...
The circadian clock, light, and cryptochrome regulate feeding and metabolism in Drosophila [0.03%]
生物钟、光线和隐花素通过调控果蝇进食行为和代谢发挥作用
Daniel J Seay,Carl S Thummel
Daniel J Seay
Recent studies in mammals have demonstrated a central role for the circadian clock in maintaining metabolic homeostasis. In spite of these advances, however, little is known about how these complex pathways are coordinated. Here, we show th...
Seasonal changes in cell proliferation in the adult sheep brain and pars tuberalis [0.03%]
绵羊大脑和结节体组织中细胞增殖的季节性变化
Martine Migaud,Martine Batailler,Delphine Pillon et al.
Martine Migaud et al.
To adapt to seasonal variations in the environment, most mammalian species exhibit seasonal cycles in their physiology and behavior. Seasonal plasticity in the structure and function of the central nervous system contributes to the adaptati...
David G Hazlerigg,Gerald A Lincoln
David G Hazlerigg
Circannual rhythms are innately timed long-term (tau ≈ 12 months) cycles of physiology and behavior, crucial for life in habitats ranging from the equator to the Poles. Here the authors propose that circannual rhythm generation depends on ...
Benjamin Schmid,Charlotte Helfrich-Förster,Taishi Yoshii
Benjamin Schmid
While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly de...