Dosing Time of Day Impacts the Safety of Antiarrhythmic Drugs in a Computational Model of Cardiac Electrophysiology [0.03%]
给药时间影响抗心律失常药物在心脏电生理学计算模型中的安全性
Ning Wei,Casey O Diekman
Ning Wei
Circadian clocks regulate many aspects of human physiology, including cardiovascular function and drug metabolism. Administering drugs at optimal times of the day may enhance effectiveness and reduce side effects. Certain cardiac antiarrhyt...
Evalien Duyvesteyn,Velia S Vizcarra,Emma Waight et al.
Evalien Duyvesteyn et al.
While there is extensive literature on both the neuronal circuitry of rhythms and the intracellular molecular clock, there is a large component of signaling that has been understudied: interstitial fluid (ISF)-fluid that surrounds the cells...
Daytime aversive stimuli do not phase shift behavioral rhythms under light-dark cycles in a strictly diurnal rodent [0.03%]
在光暗周期下，日间不良刺激不会使严格昼行性的啮齿目动物的行为节律移相
Victor Y Zhang,G J Kenagy,Horacio O de la Iglesia
Victor Y Zhang
Recent studies have shown that cyclic aversive stimuli (time-specific footshocks) act as a nonphotic zeitgeber, shifting circadian behaviors to the daytime in nocturnal rodents through entrainment. It has remained untested whether diurnal s...
Direct Temperature Responses of Bmal1 and Per2 in Reindeer Fibroblasts: Insight Into a Unique Circadian Clock Adaptation to Polar Environments [0.03%]
驯鹿成纤维细胞中Bmal1和Per2对温度的直接反应：极地环境中独特的生物钟适应性解析
S K Tahajjul Taufique
S K Tahajjul Taufique
Photoperiod-Induced Transcriptional Response in the Suprachiasmatic Nucleus [0.03%]
视交叉上核中由光照周期诱导的转录反应
Nemanja Milićević
Nemanja Milićević
Enhanced Circadian Phase Tracking: A 5-h DLMO Sampling Protocol Using Wearable Data [0.03%]
增强的昼夜节律阶段跟踪：使用可穿戴设备数据的5小时DLMO采样协议
Dongju Lim,Su Jung Choi,Yun Min Song et al.
Dongju Lim et al.
Circadian medicine aims to leverage the body's internal clock to develop safer and more effective therapeutics. Traditionally, biological time has been estimated using dim light melatonin onset (DLMO), a method that requires collecting sali...
Focusing on Excellence: An Interview With Dr. Charlotte Helfrich-Förster [0.03%]
聚焦卓越：夏洛特·贺尔弗里希-佛雷斯特博士访谈录
Sergio Hidalgo,Yao D Cai
Sergio Hidalgo
Use of Hidden Markov Models to Identify Behavioral Patterns in Accelerometry Data of Subterranean Rodents in Field Enclosures [0.03%]
在地场围栏中使用隐藏的马尔可夫模型来识别地下鼠类加速度数据中的行为模式
Milene G Jannetti,Veronica S Valentinuzzi,Gisele A Oda
Milene G Jannetti
Activity rhythms of laboratory rodents are usually measured by running wheels, and although wheel running activity-or-rest data enable straightforward rhythmic analyses, it provides limited behavioral information. In subterranean rodents (t...