Microtubule depolymerization at kinetochores restricts anaphase spindle elongation [0.03%]
着丝粒微管解聚限制了后期纺锤体伸长
Geng-Yuan Chen,Changfeng Deng,David M Chenoweth et al.
Geng-Yuan Chen et al.
Anaphase chromosome segregation depends on forces exerted by spindle microtubules. Current models propose two force-generating mechanisms: kinetochore-microtubule (kMT) depolymerization pulls chromosomes toward spindle poles (anaphase A), w...
Author Correction: Photoproximity labeling of endogenous receptors in the live mouse brain in minutes [0.03%]
作者更正：几分钟内对活体小鼠大脑內源性受体进行光 proximity 标记
Mikiko Takato,Seiji Sakamoto,Hiroshi Nonaka et al.
Mikiko Takato et al.
Published Erratum
Nature chemical biology. 2026 Jan 29. DOI:10.1038/s41589-026-02160-x 2026
Valerie Siahaan,Romana Weissova,Adela Karhanova et al.
Valerie Siahaan et al.
Tau is an axonal microtubule-associated protein. Tau interaction with microtubules is regulated by phosphorylation. Hyperphosphorylation of tau is implicated in microtubule destabilization related to neurodegenerative disorders. However, ho...
Phases align at the membrane [0.03%]
膜相组装
Katherine K Moran,Wilton T Snead
Katherine K Moran
Author Correction: PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury [0.03%]
作者更正：PAFAH2 抑制同步铁死亡以缓解急性肾损伤
Qianping Zhang,Tiantian Sun,Fan Yu et al.
Qianping Zhang et al.
Published Erratum
Nature chemical biology. 2026 Jan 26. DOI:10.1038/s41589-026-02146-9 2026
Cyntia Taveneau,Her Xiang Chai,Jovita D&#x;Silva et al.
Cyntia Taveneau et al.
CRISPR-Cas systems are transformative tools for gene editing that can be tuned or controlled by anti-CRISPRs (Acrs)-phage-derived inhibitors that regulate CRISPR-Cas activity. However, Acrs that can inhibit biotechnologically relevant CRISP...
Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers [0.03%]
靶向胸腺嘧啶DNA甘露糖酶可在p53缺陷型癌症中诱导合成致死性
Jia-Xin Zhou,Zhen-Yu Shao,Lin Zhang et al.
Jia-Xin Zhou et al.
Thymine DNA glycosylase (TDG) is a multifaceted protein involved in base-excision repair, DNA demethylation and transcriptional regulation, with key roles in embryonic development and tumorigenesis. However, the mechanisms underlying its ro...
Simon D Schwarz
Simon D Schwarz
A nucleotide code governs Lis1's ability to relieve dynein autoinhibition [0.03%]
一个核苷酸代码可调控Lis1解除dynein自身抑制的能力
Indigo C Geohring,Pengxin Chai,Bharat R Iyer et al.
Indigo C Geohring et al.
Dynein-1 is a microtubule motor that transports numerous cytoplasmic cargoes. Activation of motility requires it first overcome an autoinhibited state before its assembly with dynactin and a cargo adaptor. Studies suggest that Lis1 may reli...
Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells [0.03%]
工程化改造哺乳动物细胞中的木糖基转移酶以操控蛋白聚糖
Zhen Li,Himanshi Chawla,Lucia Di Vagno et al.
Zhen Li et al.
Mammalian cells receive signaling instructions through interactions on their surfaces. Proteoglycans are critical to these interactions, carrying long glycosaminoglycans that recruit signaling molecules. Biosynthetic redundancy in the first...