Péter Nagy,Éva Dóka,Andrea Domán et al.
Péter Nagy et al.
Reactive sulfur species (RSS) are increasingly recognized as important bioactive agents across phyla. Application of newly developed chemical tools, detection methods and multi-omics techniques has uncovered new and specific roles of endoge...
Drug-controlled CAR T cells through the regulation of cell-cell interactions [0.03%]
通过调节细胞间相互作用控制药物的CAR-T细胞
Leo Scheller,Greta Maria Paola Giordano Attianese,Rocío Castellanos-Rueda et al.
Leo Scheller et al.
Chimeric antigen receptor (CAR) T cell therapy is constrained by on-target, off-tumor toxicities and cellular exhaustion because of chronic antigen exposure. CARs incorporating small-molecule controlled on- and off-switches can enhance both...
Author Correction: Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers [0.03%]
作者更正：靶向胸腺嘧啶DNA甘露糖酶可诱导p53缺陷癌细胞合成致死性
Jia-Xin Zhou,Zhen-Yu Shao,Lin Zhang et al.
Jia-Xin Zhou et al.
Published Erratum
Nature chemical biology. 2026 Feb 18. DOI:10.1038/s41589-026-02174-5 2026
Sophie McKenna
Sophie McKenna
Grant Miura
Grant Miura
Gene Chong
Gene Chong
Francesco Pecere,Philip C Bevilacqua
Francesco Pecere
A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2 [0.03%]
一种两步机械门控机制可打开PIEZO2中的,proto-脂质孔
Shu Li,Tharaka Wijerathne,Aashish Bhatt et al.
Shu Li et al.
Mechanosensitive PIEZO channels are thought to open via tension-induced flattening of peripheral transmembrane arm domains, yet the structural basis of this activation remains unclear. Here, by leveraging hybrid-resolution molecular dynamic...
High-throughput ligand diversification to discover chemical inducers of proximity [0.03%]
高通量配体多样性化研究以发现化学诱导接近物
James B Shaum,Miquel Muñoz I Ordoño,Erica A Steen et al.
James B Shaum et al.
Chemical inducers of proximity (CIPs) stabilize biomolecular interactions, often causing an emergent rewiring of cellular biochemistry. While the discovery of heterobifunctional CIPs is expedited by rational design strategies, molecular glu...
Adhesion GPCR-induced ectocytosis mediates intercellular GPCR signal propagation [0.03%]
黏附G蛋白偶联受体诱导的胞外分泌介导细胞间G蛋白偶联受体信号传播
Guobing Huang,Ni Li,Yiyang Chen et al.
Guobing Huang et al.
Cell-cell communications involve signal transmission from sending cells to receiving cells expressing specific receptors. Extracellular vesicles (EVs) mediate this process by transporting diverse biomolecules. G-protein-coupled receptors (G...