Rūta Gerasimaitė,Gražvydas Lukinavičius
Rūta Gerasimaitė
Self-splicing and cyclization mechanisms of the full-length Anabaena pre-tRNA [0.03%]
全长度颤蓝细菌前体-tRNA的自我剪接和环化机制研究
Xiaojing Zhang,Linfeng An,Wen Yang et al.
Xiaojing Zhang et al.
Group I introns are catalytic RNAs capable of self-splicing and generating circular RNAs, processes central to RNA metabolism and biotechnology. Yet, full-length ribozyme structures containing entire exon sequences and the structural basis ...
MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation [0.03%]
MESH1充当多细胞生物的PAPS磷酸酶以调节硫酸化作用
Chao-Chieh Lin,Joshua Rose,Albert Zhang et al.
Chao-Chieh Lin et al.
Biological sulfation reactions require 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as the universal sulfate donor. While the biosynthetic pathway of PAPS has been well characterized, the phosphatase degrading PAPS remains unidentified. Her...
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment [0.03%]
用于治疗胆汁淤积性瘙痒的MRGPRX4反向激动剂的开发
Jun Yang,Ruichao Shen,Chunyu Wang et al.
Jun Yang et al.
Chronic itch, particularly in cholestatic and uremic conditions, poses a notable clinical burden, yet treatment options remain inadequate. MRGPRX4 (hX4), a bile-acid-sensing G-protein-coupled receptor predominantly expressed in human sensor...
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4 [0.03%]
分子胶CLEO4-88通过诱导结合GID4抑制ACAA1硫解酶
Chetan K Chana,Ines Ben Makhlouf,Jaeyoun Kim et al.
Chetan K Chana et al.
Molecular glues promote protein-protein interactions by enhancing the surface complementarity between proteins. Those that recruit an E3 ubiquitin ligase to a target can elicit ubiquitination and subsequent destruction of the target protein...
Recruiting without destroying [0.03%]
招聘而不毁坏
Dominika Ewa Pieńkowska,Radosław Piotr Nowak
Dominika Ewa Pieńkowska
Lighting up lipid droplets [0.03%]
点亮脂滴
Elijah Biletch,Andrew P Becker,Keriann M Backus
Elijah Biletch
Munc13-4-STX7 inhibitors impair endosomal TLR activation and systemic inflammation [0.03%]
Munc13-4-STX7抑制剂可干扰内体TLR活化和全身性炎症反应
Jennifer L Johnson,Elsa Meneses-Salas,Aparna Shukla et al.
Jennifer L Johnson et al.
Endosomal function is essential for pattern recognition receptor signaling, through endosomal Toll-like receptor (TLR) sensing of nonself RNA and DNA. The specific interaction of the calcium sensor Munc13-4 with syntaxin 7 (STX7) regulates ...
Charged molecular glue discovery enabled by targeted degron display [0.03%]
靶向degron展示 Enabled 带电分子胶的发现
Zhe Zhuang,Woong Sub Byun,Jakub Chrustowicz et al.
Zhe Zhuang et al.
Small molecules that induce protein interactions hold tremendous potential as new medicines, probes for molecular pathways and tools for agriculture. Explosive growth of targeted protein degradation drug development has spurred renewed inte...
Janine L Gray,Zhangping Xiao,Edward W Tate
Janine L Gray