Janine L Gray,Zhangping Xiao,Edward W Tate
Janine L Gray
Published Erratum
Nature chemical biology. 2026 Apr 20. DOI:10.1038/s41589-026-02226-w 2026
Lights on Src in cancer [0.03%]
癌症中的Src信号转导异常
Gene Chong
Gene Chong
A cold semi-swap [0.03%]
冷半交换
Francesco Zamberlan
Francesco Zamberlan
pH meets ivermectin [0.03%]
pH与伊维菌素见面了
Suhaila Rahman
Suhaila Rahman
A cell-permeable nanobody to restore F508del cystic fibrosis transmembrane conductance regulator activity [0.03%]
一种胞膜可渗透的纳米抗体可恢复F508DEL囊性纤维化跨膜转导调节器的作用力
Luise Franz,Tihomir Rubil,Anita Balázs et al.
Luise Franz et al.
Nanobodies are emerging as attractive biopharmaceuticals due to their small size, stability and target specificity. However, their therapeutic use has largely been restricted to extracellular targets because of a lack of efficient delivery ...
Ana Calheiros de Carvalho,Naiara Hurtado-Lopez,Carolina Cano-Prieto et al.
Ana Calheiros de Carvalho et al.
Pests cause up to 40% of global crops losses. Pesticide overuse drives resistance and poses notable risks to public health and the environment. Many hypocrealean fungi form symbiotic relationships with plants while antagonizing pests, makin...
Zikang &#x;Dennis&#x; Huang,Lukasz Bugaj
Zikang &#x;Dennis&#x; Huang
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy [0.03%]
人β管蛋白中调控紫杉醇药效的进化保守别构网络
Jingyi Luo,Chen Jing Khoo,Weixin Chen et al.
Jingyi Luo et al.
Tubulin-targeting agents such as paclitaxel have been a cornerstone of cancer treatment. However, the molecular basis by which prognosis-associated tubulin isotypes and mutations (that is, variants) affect drug efficacy remains unclear. Her...
Development of the fluorescent probe CenSpark for labeling centrioles and cilia [0.03%]
用于中心体和纤毛标记的荧光探针CenSpark的研发
Cédric Pourroy,Georgios N Hatzopoulos,Luc Reymond et al.
Cédric Pourroy et al.
Small-molecule probes are transformative for cell biology, offering unprecedented insights into subcellular structures, including in systems without molecular genetic tools. Centrioles are fundamental for generating the axoneme of cilia and...