Exploring Sex-Based Mechanisms of Inflammation and Neurodegeneration in Multiple Sclerosis [0.03%]
多发性硬化症中炎症和神经退行性变的性别差异机制探讨
Stephanie Buxhoeveden,Theresa Swift-Scanlan,Myla D Goldman et al.
Stephanie Buxhoeveden et al.
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by both immune-mediated inflammation and progressive neurodegeneration. While both processes occur in all individuals with MS, females...
DNA Methylation of SLC6A4 and NR3C1 in Term and Preterm Infants: A Pilot Study of NICU-Associated Stress [0.03%]
胎龄和早产婴儿的SLC6A4和NR3C1甲基化：与NICU相关压力相关的初步研究
Kathryn J Malin,Yvette Conley,Aleigha Barry et al.
Kathryn J Malin et al.
Background: Preterm infants requiring prolonged hospitalization in the neonatal intensive care unit (NICU) are often exposed to early-life stress, which may contribute to long-term health consequences. Epigenetic markers, particularly DNA m...
Effects of a Targeted Exercise Program on Pain, Balance, Proprioception, and Function in Adults With Knee Osteoarthritis [0.03%]
针对膝关节骨性关节炎成人患者的运动项目对其疼痛、平衡、本体感觉及功能的影响
Vahid Mohammadi,Saeedeh Mohebitabar,Gholam Rasul Mohammad Rahimi
Vahid Mohammadi
Knee osteoarthritis (OA) is associated with pain and reduced functional performance, increasing fall risk in older adults. While conventional physiotherapy is widely used, limited evidence exists regarding the added value of exercise progra...
Early Insights Into Maternal Antidepressant Use and the Human Infant Gut Microbiome [0.03%]
有关母亲使用抗抑郁药物及人类婴儿肠道微生物组的早期洞见
Katelyn Desorcy-Scherer,Kerry McNamara,Ryan Luellwitz et al.
Katelyn Desorcy-Scherer et al.
Maternal selective serotonin reuptake inhibitor (SSRI) use is common during pregnancy and lactation. Changes in serotonin signaling may affect diversity and composition of microbes in the gut. Although research suggests SSRI drives microbia...
Sex Differences in Pain Sensitivity Among Cognitively Healthy Older Adults [0.03%]
认知健康老年人的疼痛敏感度性别差异
Aaron L McDaniel,Jeffrey T Boon,Todd B Monroe et al.
Aaron L McDaniel et al.
Objective: This study examined sex differences in pain intensity and unpleasantness among cognitively healthy older adults. While females generally exhibit heightened pain sensitivity, research on sex differences in older adults remains lim...
Evaluating Sex Differences in Biomarkers of Chronic Pain Among Active-Duty Personnel: An Exploratory Analysis of a Pragmatic Clinical Trial With a SMART Design [0.03%]
一项实用临床试验中关于慢性疼痛生物标志物的性别差异评估：SMART设计的探索性分析
Sotaro Shimada,Shannon Ledesma,Diane M Flynn et al.
Sotaro Shimada et al.
Chronic pain affects approximately one-third of active-duty service members (ADSMs), yet effective treatment remains challenging. Salivary cortisol and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) are established non-invasive biomarkers of ...
Factors Associated With Obstructive Sleep Apnea Among Community-Based Overweight and Obese Type 2 Diabetes Mellitus Patients: A Multisite Cross-Sectional Study [0.03%]
社区体重超标及肥胖2型糖尿病患者阻塞性睡眠呼吸暂停的影响因素：一项多中心横断面研究
Mei-Hsiang Lin,Ping-Ru Hsiao,Ning-Hung Chen et al.
Mei-Hsiang Lin et al.
Background: Although obstructive sleep apnea (OSA) frequently coexists with type 2 diabetes mellitus (T2DM), many cases remain undiagnosed, particularly among overweight or obese individuals. Objectives: This study aimed to determine the ri...
Study Protocol for a Randomized Controlled Trial of Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants: Enhancing Stress Regulation, Neurodevelopment, and Oral Feeding Skills [0.03%]
非常早产的婴儿多重感官早期口服喂养人体母乳（M-MILK）研究方案：增强应激调节、神经发育和经口喂养技能的随机对照试验
Thao Griffith,Linda Janusek,Rosemary White-Traut et al.
Thao Griffith et al.
Background. Early life stress results in disrupted stress regulation, and less optimal neurodevelopment and oral feeding skills in very preterm infants. Despite these associations, there are few evidence-based interventions to help these fr...
The Effect of I-Shaped Kinesiotaping on Pain, Functionality, and Wound Healing After Lumbar Disc Surgery: A Randomised Controlled Trial [0.03%]
"I字形运动肌贴对腰椎间盘手术后疼痛、功能和伤口愈合影响的随机对照试验"
Gülşah Bilgin,Emine Öncü,Melih Çekinmez
Gülşah Bilgin
Background and AimKinesiotape is commonly used as a complementary therapy, but its results can vary substantially. This study aims to evaluate the effects of I-shaped kinesiotaping on patients' pain levels, functionality, and wound healing ...
Intelligent Breathing Training Using a Digital Device for Postoperative Lung Cancer Patients: A Randomized Controlled Trial [0.03%]
基于数字设备的智能呼吸训练对肺癌术后患者的随机对照试验研究
Li Chen,Jialiang Liu,Haifeng Xia et al.
Li Chen et al.
Background: Surgical resection is the primary curative treatment for lung cancer, but postoperative pulmonary dysfunction, reduced exercise tolerance, and impaired quality of life are common challenges. This study aimed to evaluate the effe...