FERONIA: A Malectin-Domain Receptor Kinase with Intricate Signaling Mechanisms and Profound Importance to Plant Wellness [0.03%]
FERONIA：一种具有复杂信号机制并对植物健康产生深远影响的Malectin-结构域受体激酶
Alice Y Cheung,Hen-Ming Wu
Alice Y Cheung
Plants have evolved elaborate signaling networks, believed to be necessitated by the diversity and complexity of their morphology, developmental and reproductive strategies, and the need to cope with an ever-changing environment from which ...
Inhibition of p16 and NF-κB Oncogenic Activity in Human Papillomavirus-Infected Cervical Cancer Cells: A New Role for Activating Transcription Factor-3 [0.03%]
激活转录因子3在人乳头瘤病毒感染的宫颈癌细胞中对p16和NF-κB肿瘤基因活性的抑制：一个新的角色
Zahra Bagheri,Haniyeh Abuei,Alireza Jaafari et al.
Zahra Bagheri et al.
Objective: Activating transcription factor 3 (ATF3) has attracted recent scientific attention as a novel mediator of tumor suppression, particularly within the context of cervical cancer (CC). Our prior research demonstrated that ATF3 overe...
ROCK2 Downregulation in Pediatric Medulloblastoma Increases Migration and Predicts the Involvement of SHH Non-canonical Signaling [0.03%]
儿童髓母细胞瘤中ROCK2下调增加迁移并预测SHH非经典信号的参与
Rodrigo Guedes Hakime,Luís Fernando Peinado Nagano,María Sol Brassesco
Rodrigo Guedes Hakime
The participation of the Rho-associated protein kinases (ROCK1 and 2) in the regulation of actin cytoskeleton organization, cell adhesion, motility, and gene expression has been extensively investigated in many tumors of different histology...
Rethinking AMPK: A Reversible Switch Fortifying Cancer Cell Stress-Resilience [0.03%]
重新思考AMPK：可逆开关增强癌症细胞的抗压能力
Shraddha S Mohanty,Shweta Warrier,Annapoorni Rangarajan
Shraddha S Mohanty
Stress adaptation is an evolutionarily conserved mechanism that promotes survival in the face of adverse conditions. AMP-activated protein kinase (AMPK) is a highly conserved energy-sensing kinase found in nearly all eukaryotic cells. It ma...
Tocilizumab for Cystoid Macular Edema Secondary to Immune Recovery Uveitis in a Patient with Contraindications to Long-Term Systemic Corticosteroid [0.03%]
托珠单抗治疗免疫重建葡萄膜炎继发的囊样黄斑水肿一例（不适宜长期全身使用皮质类固醇激素患者）
Ba Trung Nguyen,Jia-Horung Hung,Zheng Xian Thng et al.
Ba Trung Nguyen et al.
Purpose: To report a case of cystoid macular edema (CME) secondary to immune recovery uveitis (IRU) in a patient with previous history of cytomegalovirus (CMV) retinitis and leukemia, which was successfully treated with tocilizumab (TCZ), a...
Post-Acute Sequelae of SARS-CoV-2 Infections: Exercise Limitation and Rehabilitation [0.03%]
SARS-CoV-2感染后遗症：运动限制与康复治疗
Joscilin Mathew,Kenneth Nugent
Joscilin Mathew
Patients with prior SARS-CoV-2 infections can develop chronic symptoms; this clinical presentation has been called post-acute sequelae of SARS-CoV-2 infection, post-COVID condition, and long COVID. It can develop in both outpatient cases an...
Christophe Viret,Margaret S Bynoe
Christophe Viret
In relation to ancient infections, a substantial number of retroviral sequences with persistent immunogenic potential were integrated within the human genome (HERVs). Under physiological conditions, coding sequences from HERVs can participa...
Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions [0.03%]
眼部基因治疗：病毒载体、免疫反应及未来发展方向概述
Lamprini Banou,Soshian Sarrafpour,Christopher C Teng et al.
Lamprini Banou et al.
Ocular gene therapy has rapidly advanced from proof-of-concept studies to clinical trials by exploiting the unique advantages of the eye, including its easy accessibility, relative immune privilege, and the ability to use the contralateral ...
Joseph Asuam Nyarko,Patience Mawuena Dogbe,Lawrencia Ami Emefa Ativi et al.
Joseph Asuam Nyarko et al.
The Coronavirus Disease 2019 (COVID-19) pandemic, driven by the novel coronavirus and its variants, has caused over 518 million infections and 6.25 million deaths globally, leading to a significant health crisis. Beyond its primary respirat...