Overweight/Obesity and Ancestral Environmental Smoking Exposures: A Summary of Results from the ALSPAC Cohort [0.03%]
遗传环境烟草暴露与超重肥胖关系：ALSPAC队列结果概要
Sarah Watkins,Matthew Suderman,Yasmin Iles-Caven et al.
Sarah Watkins et al.
There is considerable discussion concerning the recent increase in the prevalence of overweight/obesity in children and adults. Although it is assumed that current diet and sedentary behavior are key contributors, these factors do not seem ...
Transgenerational Transmission of Epigenetic Marks During Reproduction in Arabidopsis [0.03%]
拟南芥繁殖过程中的表观遗传标签跨世代传递机制研究
Jong-Joo Cheong
Jong-Joo Cheong
Epigenetics has described non-DNA sequence-based transgenerational inheritance, in which phenotypic traits acquired over a lifetime by parents are passed to their progeny across several generations. Transgenerational epigenetic inheritance ...
Paul Holvoet
Paul Holvoet
We reviewed the role of miRNAs in the regulation of T cell differentiation and function in cardiometabolic inflammatory diseases, such as obesity, type 2 diabetes, atherosclerosis, and autoimmune diseases, such as type 1 diabetes, rheumatoi...
A Comprehensive Bioinformatic Analysis Based on Functional Studies of MEF-2 Family in NSCLC [0.03%]
基于NSCLC中MEF-2家族的功能研究的全面生物信息学分析
Yanping Wang,Gaoyang Lin,Wenwen Li et al.
Yanping Wang et al.
Lung cancer remains the malignancy with the highest morbidity and mortality worldwide. There are no effective guiding therapies and prognosis biomarkers, and the overall prognosis of lung cancer remains poor. The cardiomyocyte enhancer fact...
Pharmacoepigenetic Biomarkers in Inflammatory Bowel Diseases: A Narrative Review [0.03%]
炎症性肠病的药理表观遗传生物标志物：叙述性综述
Jatniel E Servian,Brianna Brady,Pritam Biswas et al.
Jatniel E Servian et al.
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, autoimmune disorder characterized by inflammation along the gastrointestinal tract. Global prevalence of the disease is increasin...
A Scoping Review of Epigenetic Signatures of Diet and Diet-related Metabolites: Insights from Epigenome-Wide Association Studies and Their Implications for Cardiometabolic Health and Diseases [0.03%]
饮食和与饮食相关的代谢物表观遗传特征的范围审查：来自全表观基因组关联研究的见解及其对心血管代谢健康和疾病的影响
Rameen Asif,Ruihan Liu,Russell J de Souza et al.
Rameen Asif et al.
Epigenome-wide association studies (EWASs) have emerged as a powerful approach to investigate how dietary exposures shape the epigenome and subsequently influence metabolic and cardiovascular health. A growing number of EWAS have examined t...
Tracking Epigenetic Biomarkers of Health and Aging During the Initial Year of Gender-Affirming Hormone Therapy [0.03%]
在性别肯定激素治疗初期阶段跟踪健康和衰老的表观遗传生物标志物
Khyobeni Mozhui,Beck A Henriksen,Lauren A Bell et al.
Khyobeni Mozhui et al.
Gender-affirming hormone therapy (GAHT) is a necessary treatment for many transgender people, and there is a critical need to further improve treatment experience and mitigate possible risks. Here we investigated whether DNA methylation (DN...
Epigenetic Regulation of Bone Healing: Implications for Fracture Repair and Clinical Treatment Strategies [0.03%]
表观遗传调控与骨愈合及骨折修复和临床治疗策略的关系
Sathya Subramoniam Iyer
Sathya Subramoniam Iyer
Bone healing and fracture repair are complex processes involving multiple phases that rely on coordination and differentiation of multiple cell types, such as mesenchymal stem cells (MSCs), osteoblasts, osteoclasts, chondrocytes, and endoth...
Epigenetics Through Generations and Across Phylogenies: An Interview with Dr. Bluma Lesch [0.03%]
《世代與跨種系的表觀遺傳學——對Bluma Lesch博士的一次採訪》
Reem Abu-Shamma,Andriana Marijic Buljubasic
Reem Abu-Shamma
Nanotechnology-driven Epigenetic Cancer Therapy: Precision Delivery and Sustained Release of DNA Methylation Modulators [0.03%]
纳米技术驱动的表观遗传癌症治疗：DNA甲基化调节剂的精准递送与持续释放
Usama Ahmad,Anas Islam,Mohd Muazzam Khan et al.
Usama Ahmad et al.
Aberrant DNA methylation contributes to cancer by silencing tumor suppressor genes and facilitating tumor growth. DNA methyltransferase inhibitors (DNMTis), including 5-azacytidine (5-AZA) and decitabine (DAC), can potentially mitigate thes...